TPM

TPM may refer to:

Organisations

  • Tea Party movement, an American political movement named after the Boston Tea Party
  • The Pentecostal Mission, a Pentecostal religious denomination in Tamil Nadu, India

    • Publishing

  • The Philosophers' Magazine, an independent quarterly magazine about philosophy
  • The Photographer's Mail, a photography industry magazine in New Zealand
  • Talking Points Memo, a political blog run by Joshua Marshall

    • Technology

  • Technical protection measures, the use of technological tools in order to restrict the use or access to a work
  • Tivoli Provisioning Manager, a software product by IBM
  • Total productive maintenance, an equipment maintenance program
  • Trade promotion management, software that supports the management of trade promotion
  • Trusted Platform Module, a specification for a secure cryptoprocessor included with some computers
  • TPG Telecom (Australian Securities Exchange symbol)

    • Other uses

  • Technology Park Malaysia, a research and development centre
  • Tethered particle motion, a biophysical single-molecule experiment method
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    This page contains text from Wikipedia, the Free Encyclopedia - https://wn.com/TPM

    Tropomyosin 3

    Tropomyosin alpha-3 chain is a protein that in humans is encoded by the TPM3 gene.

    This gene encodes a member of the tropomyosin family of actin-binding proteins involved in the contractile system of striated and smooth muscles and the cytoskeleton of non-muscle cells. Tropomyosins are dimers of coiled-coil proteins that polymerize end-to-end along the major groove in most actin filaments. They provide stability to the filaments and regulate access of other actin-binding proteins. In muscle cells, they regulate muscle contraction by controlling the binding of myosin heads to the actin filament. Mutations in this gene result in autosomal dominant nemaline myopathy, and oncogenes formed by chromosomal translocations involving this locus are associated with cancer. Multiple transcript variants encoding different isoforms have been found for this gene.

    References

    External links

  • GeneReviews/NCBI/NIH/UW entry on Nemaline Myopathy

    • Further reading


    Read more
    This page contains text from Wikipedia, the Free Encyclopedia - https://wn.com/Tropomyosin_3

    TPM2

    β-Tropomyosin, also known as tropomyosin beta chain is a protein that in humans is encoded by the TPM2 gene. β-tropomyosin is striated muscle-specific coiled coil dimer that functions to stabilize actin filaments and regulate muscle contraction.

    Structure

    β-tropomyosin is roughly 32 kDa in molecular weight (284 amino acids), but multiple splice variants exist. Tropomysin is a flexible protein homodimer or heterodimer composed of two alpha-helical chains, which adopt a bent coiled coil conformation to wrap around the seven actin molecules in a functional unit of muscle. It is polymerized end to end along the two grooves of actin filaments and provides stability to the filaments. Tropomyosin dimers are composed of varying combinations of tropomyosin isoforms; human striated muscles express protein from the TPM1 (α-tropoomyosin), TPM2 (β-tropomyosin) and TPM3 (γ-tropomyosin) genes, with α-tropomyosin being the predominant isoform in striated muscle. Fast skeletal muscle and cardiac muscle contain more αα-homodimers, and slow skeletal muscle contains more ββ-homodimers. In human cardiac muscle the ratio of α-tropomyosin to β-tropomyosin is roughly 5:1. It has been shown that different combinations of tropomyosin isoforms bind troponin T with differing affinities, demonstrating that isoform combinations are used to impart a specific functional impact.

    Read more
    This page contains text from Wikipedia, the Free Encyclopedia - https://wn.com/TPM2

    Podcasts:

    The People Movers

    ALBUMS

    Retro Arena Top 100

    Released 2009

    90's Club Classix Top 100

    Released 2008

    De Maxx Long Player 9

    Released 2006

    De Maxx Long Player

    Released 2001

    Dance Train Classics, Platform 3

    Released 2001

    Mixmag Presents: The Global House Experience

    Released 2000

    Warehouse Grooves: The Vibe Continues

    Released 1998

    D.J.'s United - Klub Anthems '98

    Released 1998

    Dance Mix '97

    Released 1997

    Studio Brussel: 't Gaat vooruit '97

    Released 1997

    Ballroom Tunes 9: Music From the Club La Rocca

    Released 1997

    United DJs of America, Volume 8: New York City

    Released 1997

    United DJs of America, Volume 7: New York City (Mixed by Roger Sanchez)

    Released 1997

    Solid Sounds, Format 4

    Released 1997

    Dance Train Club Edition 1997, Volume 4

    Released 1997

    C Lime Woman

    Released 1996

    TPM

    ALBUMS

    We're Still Pissed! An International Female Fronted HC/Punk Compilation, Volume 8

    Released 2013

    Love Family Trax

    Released 2002

    Frente 57

    Released 2000

    2K

    Released 1999
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    PLAYLIST TIME:

    Dopium

    by: U-God

    [Intro: U-God]
    By the time I'm finished, you gon' be a fan, muthafucka
    Trust me when I tell you
    [U-God:]
    I kick back, retire mics, take rap to higher heights
    Big back, fiend rap, blow it up, dynamite
    Sniff my China white, touchdown with king cobras
    All my life, pay the price, nickname me steamroller
    Switch lane, lean over, get brain, green Rover
    Mean soldiers run through, kung fu, break shoulders
    Rep my W, rumble through, takeover
    Heat holder, heavy best, countdown, every breath
    Last chance, tapdance, devil cop, every step
    Murderous, instinct, champions, never left
    Shaolin veteran, thug heads, never learn
    Dumb shit, every turn, hell, son, let 'em burn
    Still here, standing firm, black man in progress
    Crack dreams, conquest, burners in my arm rest
    Baby boy's a target, heads on my cannonball
    You messed up the package, the legacy, you had it all
    "Come on"
    "Come on"
    [U-God:]
    Sandstorms, kick up, millimeters blow rounds
    What happened to the music, Newburgh, Motown
    I know the low down, on half of these niggas
    Come out the closet, these Vaseline niggas
    I'm flawless, I'm lawless, all I need is one block
    Crazy legs, hat low, check out my up rock
    Respect my jumpshot, when I just, hug the rim
    Tie up my Jordans, then I jump, out the gym
    It's the Brothers Grymm, automatic coke rush
    Dice hit the walls, we gambles at the gold dust
    Descendants of the Cold Crush, long car garage doors
    One finger cake walk, nose is the concord
    Hands like windmills, possessed with the I'll skill
    Aiming for your soft spots, the scene out of Kill Bill
    "Come on"
    "Come on"
    [U-God:]
    I got the iron for your mans, one foot in the frying pan
    Rock hardhats, fireman, 8 Diagrams
    Lion eating out my hands, no it's not in Africa
    Soul brother #1, you're just a passenger
    Right before the massacre, first comes the lynching
    Caught in the mouse trap, bounce back, Redemption
    Contact the henchmen, watch how I drenched them
    Wetting with waterhose, long nose extention
    Ain't no question, you in suspended animation
    You fucked up, drop garbage tossed the side of sanitation
    Homey, you jumped up, you get lumped up, blamp your face in
    Champ in the steel cage match, snatch the foundation back
    Step on a forty gallon stage, laced with I'll grace
    Took a long time, but I'm glad that you still wait
    "Come on"




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    Inside TPM: Nicole Lafond

    TPM 07 Mar 2025
    If you want to understand the inner workings of TPM, there’s really no better person to seek out than Nicole ... Nicole first came to TPM as an editorial ...
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