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| Topoisomerase (DNA) III alpha | |||||||||||||
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| Identifiers | |||||||||||||
| Symbols | TOP3A; TOP3 | ||||||||||||
| External IDs | OMIM: 601243 MGI: 1197527 HomoloGene: 3394 GeneCards: TOP3A Gene | ||||||||||||
| EC number | 5.99.1.2 | ||||||||||||
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| RNA expression pattern | |||||||||||||
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| More reference expression data | |||||||||||||
| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 7156 | 21975 | |||||||||||
| Ensembl | ENSG00000177302 | ENSMUSG00000002814 | |||||||||||
| UniProt | Q13472 | O70157 | |||||||||||
| RefSeq (mRNA) | NM_004618.3 | NM_009410.2 | |||||||||||
| RefSeq (protein) | NP_004609.1 | NP_033436.1 | |||||||||||
| Location (UCSC) | Chr 17: 18.17 – 18.22 Mb |
Chr 11: 60.55 – 60.59 Mb |
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| PubMed search | [1] | [2] | |||||||||||
DNA topoisomerase 3-alpha is an enzyme that in humans is encoded by the TOP3A gene.[1][2]
This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This enzyme catalyzes the transient breaking and rejoining of a single strand of DNA which allows the strands to pass through one another, thus reducing the number of supercoils and altering the topology of DNA. This enzyme forms a complex with BLM which functions in the regulation of recombination in somatic cells.[2]
Interactions [link]
TOP3A has been shown to interact with Bloom syndrome protein.[3][4][5][6]
References [link]
- ^ Elsea SH, Fritz E, Schoener-Scott R, Meyn MS, Patel PI (February 1998). "Gene for topoisomerase III maps within the Smith-Magenis syndrome critical region: analysis of cell-cycle distribution and radiation sensitivity". Am J Med Genet 75 (1): 104–8. DOI:10.1002/(SICI)1096-8628(19980106)75:1<104::AID-AJMG21>3.0.CO;2-P. PMID 9450867.
- ^ a b "Entrez Gene: TOP3A topoisomerase (DNA) III alpha". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7156.
- ^ Wu, L; Davies S L, North P S, Goulaouic H, Riou J F, Turley H, Gatter K C, Hickson I D (March 2000). "The Bloom's syndrome gene product interacts with topoisomerase III". J. Biol. Chem. (UNITED STATES) 275 (13): 9636–44. DOI:10.1074/jbc.275.13.9636. ISSN 0021-9258. PMID 10734115.
- ^ Freire, R; d'Adda Di Fagagna F, Wu L, Pedrazzi G, Stagljar I, Hickson I D, Jackson S P (August 2001). "Cleavage of the Bloom's syndrome gene product during apoptosis by caspase-3 results in an impaired interaction with topoisomerase IIIα". Nucleic Acids Res. (England) 29 (15): 3172–80. DOI:10.1093/nar/29.15.3172. PMC 55826. PMID 11470874. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=55826.
- ^ Hu, P; Beresten S F, van Brabant A J, Ye T Z, Pandolfi P P, Johnson F B, Guarente L, Ellis N A (June 2001). "Evidence for BLM and Topoisomerase IIIalpha interaction in genomic stability". Hum. Mol. Genet. (England) 10 (12): 1287–98. DOI:10.1093/hmg/10.12.1287. ISSN 0964-6906. PMID 11406610.
- ^ Brosh, R M; Li J L, Kenny M K, Karow J K, Cooper M P, Kureekattil R P, Hickson I D, Bohr V A (August 2000). "Replication protein A physically interacts with the Bloom's syndrome protein and stimulates its helicase activity". J. Biol. Chem. (UNITED STATES) 275 (31): 23500–8. DOI:10.1074/jbc.M001557200. ISSN 0021-9258. PMID 10825162.
Further reading [link]
- Hanai R, Caron PR, Wang JC (1996). "Human TOP3: a single-copy gene encoding DNA topoisomerase III". Proc. Natl. Acad. Sci. U.S.A. 93 (8): 3653–7. DOI:10.1073/pnas.93.8.3653. PMC 39666. PMID 8622991. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=39666.
- Fritz E, Elsea SH, Patel PI, Meyn MS (1997). "Overexpression of a truncated human topoisomerase III partially corrects multiple aspects of the ataxia-telangiectasia phenotype". Proc. Natl. Acad. Sci. U.S.A. 94 (9): 4538–42. DOI:10.1073/pnas.94.9.4538. PMC 20758. PMID 9114025. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=20758.
- Kim JC, Yoon JB, Koo HS, Chung IK (1998). "Cloning and characterization of the 5'-flanking region for the human topoisomerase III gene". J. Biol. Chem. 273 (40): 26130–7. DOI:10.1074/jbc.273.40.26130. PMID 9748294.
- Goulaouic H, Roulon T, Flamand O et al. (1999). "Purification and characterization of human DNA topoisomerase IIIalpha". Nucleic Acids Res. 27 (12): 2443–50. DOI:10.1093/nar/27.12.2443. PMC 148446. PMID 10352172. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=148446.
- Shimamoto A, Nishikawa K, Kitao S, Furuichi Y (2000). "Human RecQ5β, a large isomer of RecQ5 DNA helicase, localizes in the nucleoplasm and interacts with topoisomerases 3α and 3β". Nucleic Acids Res. 28 (7): 1647–55. DOI:10.1093/nar/28.7.1647. PMC 102787. PMID 10710432. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=102787.
- Wu L, Davies SL, North PS et al. (2000). "The Bloom's syndrome gene product interacts with topoisomerase III". J. Biol. Chem. 275 (13): 9636–44. DOI:10.1074/jbc.275.13.9636. PMID 10734115.
- Lin CW, Darzynkiewicz Z, Li X et al. (2000). "Differential expression of human topoisomerase IIIalpha during the cell cycle progression in HL-60 leukemia cells and human peripheral blood lymphocytes". Exp. Cell Res. 256 (1): 225–36. DOI:10.1006/excr.1999.4778. PMID 10739669.
- Brosh RM, Li JL, Kenny MK et al. (2000). "Replication protein A physically interacts with the Bloom's syndrome protein and stimulates its helicase activity". J. Biol. Chem. 275 (31): 23500–8. DOI:10.1074/jbc.M001557200. PMID 10825162.
- Lodge AJ, Anderson JJ, Ng SW et al. (2000). "Expression of topoisomerase III α in normal and neoplastic tissues determined by immunohistochemistry using novel monoclonal antibody". Br. J. Cancer 83 (4): 498–505. DOI:10.1054/bjoc.2000.1293. PMC 2374664. PMID 10945498. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2374664.
- Hu P, Beresten SF, van Brabant AJ et al. (2001). "Evidence for BLM and Topoisomerase IIIalpha interaction in genomic stability". Hum. Mol. Genet. 10 (12): 1287–98. DOI:10.1093/hmg/10.12.1287. PMID 11406610.
- Freire R, d'Adda Di Fagagna F, Wu L et al. (2001). "Cleavage of the Bloom's syndrome gene product during apoptosis by caspase-3 results in an impaired interaction with topoisomerase IIIα". Nucleic Acids Res. 29 (15): 3172–80. DOI:10.1093/nar/29.15.3172. PMC 55826. PMID 11470874. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=55826.
- Bi W, Yan J, Stankiewicz P et al. (2002). "Genes in a Refined Smith-Magenis Syndrome Critical Deletion Interval on Chromosome 17p11.2 and the Syntenic Region of the Mouse". Genome Res. 12 (5): 713–28. DOI:10.1101/gr.73702. PMC 186594. PMID 11997338. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=186594.
- Wang Y, Lyu YL, Wang JC (2002). "Dual localization of human DNA topoisomerase IIIα to mitochondria and nucleus". Proc. Natl. Acad. Sci. U.S.A. 99 (19): 12114–9. DOI:10.1073/pnas.192449499. PMC 129407. PMID 12209014. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=129407.
- Wu L, Hickson ID (2002). "The Bloom's syndrome helicase stimulates the activity of human topoisomerase IIIα". Nucleic Acids Res. 30 (22): 4823–9. DOI:10.1093/nar/gkf611. PMC 137159. PMID 12433984. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=137159.
- Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. DOI:10.1073/pnas.242603899. PMC 139241. PMID 12477932. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
- Meetei AR, de Winter JP, Medhurst AL et al. (2003). "A novel ubiquitin ligase is deficient in Fanconi anemia". Nat. Genet. 35 (2): 165–70. DOI:10.1038/ng1241. PMID 12973351.
- Jiao R, Bachrati CZ, Pedrazzi G et al. (2004). "Physical and Functional Interaction between the Bloom's Syndrome Gene Product and the Largest Subunit of Chromatin Assembly Factor 1". Mol. Cell. Biol. 24 (11): 4710–9. DOI:10.1128/MCB.24.11.4710-4719.2004. PMC 416397. PMID 15143166. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=416397.
- Gerhard DS, Wagner L, Feingold EA et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. DOI:10.1101/gr.2596504. PMC 528928. PMID 15489334. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.
- Yin J, Sobeck A, Xu C et al. (2005). "BLAP75, an essential component of Bloom's syndrome protein complexes that maintain genome integrity". EMBO J. 24 (7): 1465–76. DOI:10.1038/sj.emboj.7600622. PMC 1142546. PMID 15775963. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1142546.
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