| Transcription termination factor, RNA polymerase I | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||||||
| Symbols | TTF1; TTF-1; TTF-I | ||||||||||||
| External IDs | OMIM: 600777 MGI: 105044 HomoloGene: 49133 GeneCards: TTF1 Gene | ||||||||||||
|
|||||||||||||
| RNA expression pattern | |||||||||||||
 |
|||||||||||||
 |
|||||||||||||
| More reference expression data | |||||||||||||
| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 7270 | 22130 | |||||||||||
| Ensembl | ENSG00000125482 | ENSMUSG00000026803 | |||||||||||
| UniProt | Q15361 | Q62187 | |||||||||||
| RefSeq (mRNA) | NM_001205296.1 | NM_009442.2 | |||||||||||
| RefSeq (protein) | NP_001192225.1 | NP_033468.2 | |||||||||||
| Location (UCSC) | Chr 9: 135.25 – 135.28 Mb |
Chr 2: 28.92 – 28.94 Mb |
|||||||||||
| PubMed search | [1] | [2] | |||||||||||
Transcription termination factor 1 is a protein that in humans is encoded by the TTF1 gene.[1][2]
References [link]
- ^ Evers R, Grummt I (Aug 1995). "Molecular coevolution of mammalian ribosomal gene terminator sequences and the transcription termination factor TTF-I". Proc Natl Acad Sci U S A 92 (13): 5827–31. DOI:10.1073/pnas.92.13.5827. PMC 41594. PMID 7597036. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=41594.
- ^ "Entrez Gene: TTF1 transcription termination factor, RNA polymerase I". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7270.
Further reading [link]
- Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. DOI:10.1016/0378-1119(94)90802-8. PMID 8125298.
- Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791–806. DOI:10.1101/gr.6.9.791. PMID 8889548.
- Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. DOI:10.1016/S0378-1119(97)00411-3. PMID 9373149.
- Jansa P, Mason SW, Hoffmann-Rohrer U, Grummt I (1998). "Cloning and functional characterization of PTRF, a novel protein which induces dissociation of paused ternary transcription complexes.". EMBO J. 17 (10): 2855–64. DOI:10.1093/emboj/17.10.2855. PMC 1170626. PMID 9582279. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1170626.
- Muth V, Nadaud S, Grummt I, Voit R (2001). "Acetylation of TAF(I)68, a subunit of TIF-IB/SL1, activates RNA polymerase I transcription.". EMBO J. 20 (6): 1353–62. DOI:10.1093/emboj/20.6.1353. PMC 145524. PMID 11250901. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=145524.
- Strohner R, Nemeth A, Jansa P, et al. (2001). "NoRC--a novel member of mammalian ISWI-containing chromatin remodeling machines.". EMBO J. 20 (17): 4892–900. DOI:10.1093/emboj/20.17.4892. PMC 125270. PMID 11532953. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=125270.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. DOI:10.1073/pnas.242603899. PMC 139241. PMID 12477932. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
- Humphray SJ, Oliver K, Hunt AR, et al. (2004). "DNA sequence and analysis of human chromosome 9.". Nature 429 (6990): 369–74. DOI:10.1038/nature02465. PMC 2734081. PMID 15164053. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2734081.
- Colland F, Jacq X, Trouplin V, et al. (2004). "Functional proteomics mapping of a human signaling pathway.". Genome Res. 14 (7): 1324–32. DOI:10.1101/gr.2334104. PMC 442148. PMID 15231748. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=442148.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. DOI:10.1101/gr.2596504. PMC 528928. PMID 15489334. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.
- Nousiainen M, Silljé HH, Sauer G, et al. (2006). "Phosphoproteome analysis of the human mitotic spindle.". Proc. Natl. Acad. Sci. U.S.A. 103 (14): 5391–6. DOI:10.1073/pnas.0507066103. PMC 1459365. PMID 16565220. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1459365.
- Takano T, Ito Y, Matsuzuka F, et al. (2007). "Quantitative measurement of telomerase reverse transcriptase, thyroglobulin and thyroid transcription factor 1 mRNAs in anaplastic thyroid carcinoma tissues and cell lines.". Oncol. Rep. 18 (3): 715–20. PMID 17671725.
 |
This article on a gene on chromosome 9 is a stub. You can help Wikipedia by expanding it. |
https://wn.com/Transcription_termination_factor,_RNA_polymerase_I
NK2 homeobox 1
NK2 homeobox 1 (NKX2-1), also known as thyroid transcription factor 1 (TTF-1), is a protein which in humans is encoded by the NKX2-1 gene.
Function
Thyroid transcription factor-1 (TTF-1) is a protein that regulates transcription of genes specific for the thyroid, lung, and diencephalon. It is also known as thyroid specific enhancer binding protein. It is used in anatomic pathology as a marker to determine if a tumor arises from the lung or thyroid. NKX2.1 can be induced by activin A via SMAD2 signaling in a human embryonic stem cell differentiation model.
Clinical significance
TTF-1 positive cells are found in the lung as type II pneumocytes and club cells. In the thyroid, follicular and parafollicular cells are also positive for TTF-1.
For lung cancers, adenocarcinomas are usually positive, while squamous cell carcinomas and large cell carcinomas are rarely positive. Small cell carcinomas (of any primary site) are usually positive. TTF1 is more than merely a clinical marker of lung adenocarcinoma. It plays an active role in sustaining lung cancer cells in view of the experimental observation that it is mutated in lung cancer.
Podcasts:
-
by Pigface
T F W O
by: PigfaceT.F.W.O. [x3]
totally fucking weirded out
treason trapping
animal hide
in the vision of paradise
two explains your head
deranged
time spun web deluded of life
wicked black witch lady localize
inteligensia
go write a book and cry in it
face it lost that look
survivals hard enough
fading fire burning higher
time to realize that i'm on fire
patience sun the lord looks over
who covers in the watchtower
freeze arm scraping inches the vein
blind distracted the worshipping
metal point
a scraping hole
forever breaking
in out
temper test
bottom so vile
fading fire burning higher
time to realize that i'm on fire
T.F.W.O.
T.F.W.O.
totally fucking weirded out
T.F.W.O. [x3]
...weirded out
fading fire burning higher
time to realize that i'm on fire
fading higher why you liar?
it made inside my brain i don't remember
fading higher why you liar?
T.F.W.O. [x9]
F.F.F.F.F.F.F.F.F.F.F.F.F.F.F.F.F.F...
F....F....F....F....F....