Tir, tir or TIR may mean:
Tir (translocated intimin receptor) is an essential component in the adherence of the enteropathogenic Escherichia coli (EPEC) and enterohemorraghic Escherichia coli to the cells lining the small intestine. To aid attachment, both EPEC and EHEC possess the ability to reorganise the host cell actin cytoskeleton via the secretion of virulence factors. These factors are secreted directly into the cells using a Type three secretion system. One of the virulence factors secreted is the Translocated Intimin Receptor (Tir). Tir is a receptor protein encoded by the espE gene which is located on the locus of enterocyte effacement (LEE) pathogenicity island in EPEC strains. It is secreted into the host cell membranes and acts as a receptor for intimin which is found on the bacterial surface. Once Tir binds intimin, the bacterium is attached to the enterocyte surface.
Tir is also a receptor tyrosine kinase (RTK) that initiates its intimate adherence by inserting a hairpin orientation in the intestinal cell membrane to enable tight binding to intimin on the bacterial cell outer membrane. Upon phosphorylation, Tir activates condensation and polymerization of actin filaments under the bacterial cell to form a pedestal-like structure.
Tir (Persian: تیر, Persian pronunciation: [tiːɾ]) is the fourth month of the Iranian calendar. It begins in June and ends in July of the Gregorian calendar. Tir has thirty-one days, spanning June and July in the Gregorian calendar.
Tir is the first month of summer, and is followed by Mordad.
I love You, Lord, I worship You
I love You, Lord, always
So thankful Lord, You saved my life
You saved my life today
Let me be a shining light for You
Let me be a joy to You always
Let me be a shining light for You
Let me be a joy to You always, yeah, yeah
No Superman, I'm no hero
I'm just a man in Your eyes
But through Your son I've overcome
The Father of all lies
Let me be a shining light for You
Let me be a joy to You always
Let me be a shining light for You
Let me be a joy to You always, yeah, yeah, yeah
Hallelujah, Hallelujah
Hallelujah, Hallelujah
No Superman, I'm no hero
I'm just a man in Your eyes
But through Your son I've overcome
The Father of all lies
Let me be a shining light for You
Let me be a shining light for You
Let me be a joy to You always
Let me be a shining light for You
Let me be a joy to You always
Let me be a shining light for You
Let me be a joy to You always
Let me be a shining light for You
Let me be a joy to You always
Let me be a joy to You always
Let me be a joy to You always
I wanna be a joy to You always
Let me be a joy to You always
Hallelujah, Hallelujah