TIMP2
TIMP metallopeptidase inhibitor 2, a tissue inhibitor of metalloproteinases, also known as TIMP2, is a human gene, thought to be a metastasis suppressor.
Function
This gene is a member of the TIMP gene family. The proteins encoded by this gene family are natural inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix. In addition to an inhibitory role against metalloproteinases, the encoded protein has a unique role among TIMP family members in its ability to directly suppress the proliferation of endothelial cells. As a result, the encoded protein may be critical to the maintenance of tissue homeostasis by suppressing the proliferation of quiescent tissues in response to angiogenic factors, and by inhibiting protease activity in tissues undergoing remodelling of the extracellular matrix. TIMP-2 functions as both an MMP inhibitor and an activator. TIMPs inhibit all active MMPs, but different TIMPs inhibit different MMPs better than other TIMPs. For example, TIMP-1 inhibits MMP-7, MMP-9, MMP-1 and MMP-3 better than TIMP-2, and TIMP-2 inhibits MMP-2 more effectively than other TIMPs.
Podcasts:
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by Prince
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by The Crow soundtrack
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by Medicine
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by The Honeyz
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by Honeyz
Do Me Baby
by: PrinceHere we are in this big old empty room, staring each other down
U want me just as much as I want u, lets stop fooling around
Take me baby... kiss me all over... play with my love
Bring out what's been in me for far too long
Baby, u know that's all Ive been dreaming of
Do me baby, like u never done before
Give it to me till I just can't take no more
Do me baby, like u never done before
I want u now, I just can't wait no more, can't wait...
Here we are looking for a reason for u to lay me down
For a love like ours is never out of season, so baby please stop teasing me
What ya do, I can never love no other, ure the best I ever had
Whenever were not close to one another, I just want u so bad
So do me baby, like u never done before
Give it to me till I just can't take no more
Cmon, do me baby, like u never done before
I want u now, I just can't wait no more
I said ooo...ooo...oooo...ooooooo
Do me baby, do me baby, give it to me
Do me baby, I want u now
Do me baby, give it to me
Do me baby, do me baby, don't wanna do it all alone
I want your love.
Do me baby, give it to me
Do me baby, this feeling is too strong, make me wait 2 long, I want u now
Youre leaving me no choice
Ok, what are u gonna do...u just gonna sit there and watch? alright...
Are u sure u don't wanna close your eyes?
...well, isn't it supposed to take a long time?
Im not gonna stop till the war is over...
Help me! there...ok...ok