Transcription factor II Human (TFIIH) is one of several general transcription factors that make up the RNA polymerase II preinitiation complex. TFIIH consists of ten subunits, 7 of which (XPD, XPB, p62, p52, p44, p34 and TTDA) form the core complex. The cyclin activating kinase-subcomplex (CDK7, MAT1, and cyclin H) is linked to the core via the XPD protein Two of the subunits, ERCC2/XPD and ERCC3/XPB, have helicase and ATPase activities and help create the transcription bubble. In a test tube these subunits are only required for transcription if the DNA template is not already denatured or if it is supercoiled.
Two other TFIIH subunits, CDK7 and cyclin H, phosphorylate serine amino acids on the RNA polymerase II C-terminal domain and possibly other proteins involved in the cell cycle. Next to a vital function in transcription initiation, TFIIH is also involved in nucleotide excision repair.
It is responsible for giving the 'go' signal which is why it is assembled last.
SOMEONE SAID THAT
NO ONE KNOWS WHAT
GOES ON INSIDE
SOMEONE IN LOVE
STRANGE AS IT SEEMS
IT MAKES THEM DO THINGS
IN THEIR RIGHT MINDS
WOULD NEVER THINK OF
PEOPLE GET AWAY WITH THINGS
THEY DON'T DESERVE
A JURISDICTION OF LOVE
ENOUGH'S NOT ENOUGH
WHEN LOVE GETS ROUGH
THE JURISDICTION OF LOVE
OFF THEIR WALLS
JUST LIKE NIAGARA FALLS
LOGICAL THOUGHT
IS NO COMFORT
IT ONLY MAKES THE
MATTER SEEM WORSE
MIGHT EQUALS RIGHT
IN CONCUBIAL FIGHT
THE JURISDICTION OF LOVE
LOVE EQUALS WAR
I DON'T LIKE IT NO MORE
THE JURISDICTION OF LOVE
PEOPLE GET AWAY WITH THINGS
THEY DON'T DESERVE
A JURISDICTION OF LOVE
WHEN LOVE TURNS THE CRANK
IT DEMANDS CARTE BLANCHE