TFF may stand for:
Trefoil factor 2 is a protein that in humans is encoded by the TFF2 gene.
Members of the trefoil family are characterized by having at least one copy of the trefoil motif, a 40-amino acid domain that contains three conserved disulfides. They are stable secretory proteins expressed in gastrointestinal mucosa. Their functions are not defined, but they may protect the mucosa from insults, stabilize the mucus layer and affect healing of the epithelium. The encoded protein inhibits gastric acid secretion. This gene and two other related trefoil family member genes are found in a cluster on chromosome 21.
Trefoil factor 3 is a protein that in humans is encoded by the TFF3 gene.
Members of the trefoil family are characterized by having at least one copy of the trefoil motif, a 40-amino acid domain that contains three conserved disulfide bonds. They are stable secretory proteins expressed in gastrointestinal mucosa. Their functions are not defined, but they may protect the mucosa from insults, stabilize the mucus layer and affect healing of the epithelium. This gene is a marker of columnar epithelium and is expressed in a variety of tissues including goblet cells of the intestines and colon. This gene and two other related trefoil family member genes are found in a cluster on chromosome 21.
Trefoil factors (TFF) are secretory products of mucin producing cells. They play a key role in the maintenance of the surface integrity of oral mucosa and enhance healing of the gastrointestinal mucosa by a process called restitution. TFF comprises the gastric peptides (TFF1), spasmolytic peptide (TFF2), and the intestinal trefoil factor (TFF3, this protein). They have an important and necessary role in epithelial restitution within the gastrointestinal tract. Significant amounts of TFF are present in human milk. Evidence has been presented that TFF3 isolated from milk strongly correlates with downregulation of IL-6 and IL-8 in human intestinal epithelial cells. On the other hand, TFF3 activated the epithelial cells in culture to produce beta defensins 2 (hBD2) and beta defensins 4 (hBD4). These findings suggest that TFF can activate intestinal epithelial cells and could actively participate in the immune system of breastfed babies by inducing the production of peptides related to innate defence, such as defensins.
SOMEONE SAID THAT
NO ONE KNOWS WHAT
GOES ON INSIDE
SOMEONE IN LOVE
STRANGE AS IT SEEMS
IT MAKES THEM DO THINGS
IN THEIR RIGHT MINDS
WOULD NEVER THINK OF
PEOPLE GET AWAY WITH THINGS
THEY DON'T DESERVE
A JURISDICTION OF LOVE
ENOUGH'S NOT ENOUGH
WHEN LOVE GETS ROUGH
THE JURISDICTION OF LOVE
OFF THEIR WALLS
JUST LIKE NIAGARA FALLS
LOGICAL THOUGHT
IS NO COMFORT
IT ONLY MAKES THE
MATTER SEEM WORSE
MIGHT EQUALS RIGHT
IN CONCUBIAL FIGHT
THE JURISDICTION OF LOVE
LOVE EQUALS WAR
I DON'T LIKE IT NO MORE
THE JURISDICTION OF LOVE
PEOPLE GET AWAY WITH THINGS
THEY DON'T DESERVE
A JURISDICTION OF LOVE
WHEN LOVE TURNS THE CRANK
IT DEMANDS CARTE BLANCHE