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| Thyrotrophic embryonic factor | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||||||
| Symbols | TEF[] | ||||||||||||
| External IDs | OMIM: 188595 MGI: 98663 HomoloGene: 31140 GeneCards: TEF Gene | ||||||||||||
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| RNA expression pattern | |||||||||||||
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| More reference expression data | |||||||||||||
| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 7008 | 21685 | |||||||||||
| Ensembl | ENSG00000167074 | ENSMUSG00000022389 | |||||||||||
| UniProt | Q10587 | Q9JLC6 | |||||||||||
| RefSeq (mRNA) | NM_001145398.2 | NM_017376.3 | |||||||||||
| RefSeq (protein) | NP_001138870.1 | NP_059072.1 | |||||||||||
| Location (UCSC) | Chr 22: 41.76 – 41.8 Mb |
Chr 15: 81.63 – 81.66 Mb |
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| PubMed search | [1] | [2] | |||||||||||
Thyrotroph embryonic factor is a protein that in humans is encoded by the TEF gene.[1][2][3]
Thyrotroph embryonic factor (TEF), a transcription factor, is a member of the PAR (proline and acidic amino acid-rich) subfamily of basic region/leucine zipper (bZIP) transcription factors. It is expressed in a broad range of cells and tissues in adult animals, however, during embryonic development, TEF expression appears to be restricted to the developing anterior pituitary gland, coincident with the appearance of thyroid-stimulating hormone, beta (TSHB). Indeed, TEF can bind to, and transactivate the TSHB promoter. It shows homology (in the functional domains) with other members of the PAR-bZIP subfamily of transcription factors, which include albumin D box-binding protein (DBP), human hepatic leukemia factor (HLF) and chicken vitellogenin gene-binding protein (VBP); VBP is considered the chicken homologue of TEF. Different members of the subfamily can readily form heterodimers, and share DNA-binding, and transcriptional regulatory properties.[3]
References [link]
- ^ Khatib ZA, Inaba T, Valentine M, Look AT (Feb 1995). "Chromosomal localization and cDNA cloning of the human DBP and TEF genes". Genomics 23 (2): 344–51. DOI:10.1006/geno.1994.1510. PMID 7835883.
- ^ Inukai T, Inaba T, Dang J, Kuribara R, Ozawa K, Miyajima A, Wu W, Look AT, Arinobu Y, Iwasaki H, Akashi K, Kagami K, Goi K, Sugita K, Nakazawa S (May 2005). "TEF, an antiapoptotic bZIP transcription factor related to the oncogenic E2A-HLF chimera, inhibits cell growth by down-regulating expression of the common beta chain of cytokine receptors". Blood 105 (11): 4437–44. DOI:10.1182/blood-2004-08-2976. PMID 15665112.
- ^ a b "Entrez Gene: TEF thyrotrophic embryonic factor". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7008.
Further reading [link]
- Drolet DW, Scully KM, Simmons DM, et al. (1991). "TEF, a transcription factor expressed specifically in the anterior pituitary during embryogenesis, defines a new class of leucine zipper proteins". Genes Dev. 5 (10): 1739–53. DOI:10.1101/gad.5.10.1739. PMID 1916262.
- Hunger SP, Li S, Fall MZ, et al. (1996). "The proto-oncogene HLF and the related basic leucine zipper protein TEF display highly similar DNA-binding and transcriptional regulatory properties". Blood 87 (11): 4607–17. PMID 8639829.
- Ossipow V, Fonjallaz P, Schibler U (1999). "An RNA Polymerase II Complex Containing All Essential Initiation Factors Binds to the Activation Domain of PAR Leucine Zipper Transcription Factor Thyroid Embryonic Factor". Mol. Cell. Biol. 19 (2): 1242–50. PMC 116053. PMID 9891058. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=116053.
- Dunham I, Shimizu N, Roe BA, et al. (1999). "The DNA sequence of human chromosome 22". Nature 402 (6761): 489–95. DOI:10.1038/990031. PMID 10591208.
- Krueger DA, Warner EA, Dowd DR (2000). "Involvement of thyrotroph embryonic factor in calcium-mediated regulation of gene expression". J. Biol. Chem. 275 (19): 14524–31. DOI:10.1074/jbc.275.19.14524. PMID 10799536.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. DOI:10.1073/pnas.242603899. PMC 139241. PMID 12477932. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
- Newman JR, Keating AE (2003). "Comprehensive identification of human bZIP interactions with coiled-coil arrays". Science 300 (5628): 2097–101. DOI:10.1126/science.1084648. PMID 12805554.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. DOI:10.1038/ng1285. PMID 14702039.
- Collins JE, Wright CL, Edwards CA, et al. (2005). "A genome annotation-driven approach to cloning the human ORFeome". Genome Biol. 5 (10): R84. DOI:10.1186/gb-2004-5-10-r84. PMC 545604. PMID 15461802. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=545604.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. DOI:10.1101/gr.2596504. PMC 528928. PMID 15489334. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.
- Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. DOI:10.1038/nature04209. PMID 16189514.
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Gene
A gene is a locus (or region) of DNA that encodes a functional RNA or protein product, and is the molecular unit of heredity. The transmission of genes to an organism's offspring is the basis of the inheritance of phenotypic traits. Most biological traits are under the influence of polygenes (many different genes) as well as the gene–environment interactions. Some genetic traits are instantly visible, such as eye colour or number of limbs, and some are not, such as blood type, risk for specific diseases, or the thousands of basic biochemical processes that comprise life.
Genes can acquire mutations in their sequence, leading to different variants, known as alleles, in the population. These alleles encode slightly different versions of a protein, which cause different phenotype traits. Colloquial usage of the term "having a gene" (e.g., "good genes," "hair colour gene") typically refers to having a different allele of the gene. Genes evolve due to natural selection or survival of the fittest of the alleles.
Eugene (given name)
Eugene is a common (masculine) first name that comes from the Greek εὐγενής (eugenēs), "noble", literally "well-born", from εὖ (eu), "well" and γένος (genos), "race, stock, kin".Gene is a common shortened form. The feminine variant is Eugenia or Eugénie.
Male foreign-language variants include:
Notable people
Christianity
Military
Gene (novel)
Gene is a thriller novel by Stel Pavlou (born 1970), published in 2005 in England by Simon & Schuster. It is published in several languages with some title changes. The Italian edition has the title La Conspirazione del Minotauro (The Minotaur Conspiracy). The novel is about a fictional New York detective, James North, who in the process of hunting down a criminal, uncovers a genetics experiment to unlock past lives through genetic memory, therefore achieving a kind of immortality. In so doing North discovers his own origins, that of a soldier from the Trojan War who is reincarnated seven times through history, forced to confront his nemesis each time, all for the loss of his one true love.
Characters
Cyclades (born circa 1300 BC)
Incarnations of Cyclades
Athanatos (born circa 1500 BC)
Incarnations of Athanatos
Tefé
Tefé (Teffé in early accounts) is a municipality in the state of Amazonas, northern Brazil. It is located about 525 km by air or 595 km by river to the west of Manaus on the south bank of the Rio Solimões (the upper Amazon), on the lake formed by the mouth of the Tefé River. The nearest large city is Coari, 192 km SE by east of Tefé.
Tefé is the largest town and commercial center of the middle Solimões region. Its population was 61,453 (IBGE 2010) evenly divided between urban and rural, and its area is 23,704 km². There are no roads into Tefé and the only access is by river boat or plane. By fast boat it is about 12 hours from Manaus. TRIP Linhas Aereas operate flights from Manaus to Tefé Airport.
The city is the home of the Territorial Prelature of Tefé. Tefé is also the major starting point for trips into the Mamiraua Reserve.
History
As early as 1620 the Portuguese Carmelites could already boast of converts among the Muras, those natives of the Amazon established around Lake Teffé and on the borders of the neighbouring rivers. Tefé, also called Ega at one time, was the fourth of eight aldeias founded by Carmelite missionaries between 1697 and 1751 along the Solimões and Negro Rivers. In 1759 the commandant Joaquim de Mello da Povoas converted the Carmelite mission on Lake Tefé into a town, which he named Ega; it was elevated to a city named Tefé in 1855 (but was known as Tefé before that time). The mission, called Parauarí, was originally established on Ilha dos Veados three leagues from the location on the opposite shore of Lake Tefe, called today by the name of Nogueira. The survivors were taken to its present site by F. Andre da Costa in 1817. It was abandoned due to a smallpox outbreak in the early 18th century and moved across the lake, where it remains today.
Tef
Tef or TEF may refer to:
Teaching Excellence Framework, a UK Government initiative
Tellurium hexafluoride
Tellurium hexafluoride is a chemical compound of tellurium and fluorine with the chemical formula TeF6. It is a colorless, highly toxic gas with an extremely unpleasant smell.
Preparation
Tellurium hexafluoride is most commonly prepared by passing fluorine gas over tellurium at 150 °C. Below this temperature a mixture of lower fluorides form, including tellurium tetrafluoride and ditellurium decafluoride. It can also be prepared by passing fluorine gas over TeO3 or indirectly by reacting TeO2 with SeF4 to produce TeF4 and then heating TeF4 in excess of 200 °C to make TeF6 and Te.
Properties
Tellurium hexafluoride is a highly symmetric octahedral molecule. Its physical properties resemble the sulfur and selenium analogs. It is less volatile, however, due to the increase in molecular weight. At temperatures below −38 °C, tellurium hexafluoride condenses to a volatile white solid.
Reactivity
Unlike the sulfur analog, tellurium hexafluoride is not chemically inert. This can be attributed to the larger atomic radius which can co-ordinate a maximum of eight atoms rather than six for sulfur and selenium which allows for nucleophilic attack. TeF6 is hydrolyzed in water to Te(OH)6 and reacts with Te below 200 °C.
