Transporter Classification Database

Transporter Classification Database (or TCDB) is an International Union of Biochemistry and Molecular Biology (IUBMB) approved classification system for membrane transport proteins including ion channels. This classification system was designed to be analogous to the EC number system for classifying enzymes, but it also uses phylogenetic information.

Classification

The upper level of classification and a few examples of proteins with known 3D structure:

1. Channels/Pores

1.A α-Type channels

  • 1.A.1 Voltage-gated ion channel superfamily
  • 1.A.2 Animal inward-rectifier K+ channel
  • 1.A.3 Ryanodine-inositol-1,4,5-trisphosphate receptor Ca2+ channel
  • 1.A.4 Transient receptor potential Ca2+ channel
  • 1.A.5 Polycystin cation channel
  • 1.A.6 Epithelial Na+ channel
  • 1.A.7 ATP-gated cation channel
  • 1.A.8 Major intrinsic protein
  • 1.A.9 Ligand-gated ion channel of neurotransmitter receptors
  • 1.A.10 Glutamate-gated ion channel of neurotransmitter receptors
  • 1.A.11 Chloride channel
  • 1.A.12 Organellar chloride channel
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