TBCD

Tubulin-specific chaperone D is a protein that in humans is encoded by the TBCD gene.

Function

Cofactor D is one of four proteins (cofactors A, D, E, and C) involved in the pathway leading to correctly folded beta-tubulin from folding intermediates. Cofactors A and D are believed to play a role in capturing and stabilizing beta-tubulin intermediates in a quasi-native confirmation. Cofactor E binds to the cofactor D/beta-tubulin complex; interaction with cofactor C then causes the release of beta-tubulin polypeptides that are committed to the native state.

Interactions

TBCD has been shown to interact with ARL2.

References

Further reading

Binary-coded decimal

In computing and electronic systems, binary-coded decimal (BCD) is a class of binary encodings of decimal numbers where each decimal digit is represented by a fixed number of bits, usually four or eight. Special bit patterns are sometimes used for a sign or for other indications (e.g., error or overflow).

In byte-oriented systems (i.e. most modern computers), the term unpacked BCD usually implies a full byte for each digit (often including a sign), whereas packed BCD typically encodes two decimal digits within a single byte by taking advantage of the fact that four bits are enough to represent the range 0 to 9. The precise 4-bit encoding may vary however, for technical reasons, see Excess-3 for instance. The ten states representing a BCD decimal digit are sometimes called tetrades (for the nibble typically needed to hold them also known as tetrade) with those don't care-states unused named pseudo-tetrad(e)s or pseudo-decimal digit).

BCD's main virtue is its more accurate representation and rounding of decimal quantities as well as an ease of conversion into human-readable representations, in comparison to binary positional systems. BCD's principal drawbacks are a small increase in the complexity of the circuits needed to implement basic arithmetics and a slightly less dense storage.