TARDBP
TAR DNA-binding protein 43 (TDP-43, transactive response DNA binding protein 43 kDa), is a protein that in humans is encoded by the TARDBP gene.
Function
TDP-43 is a transcriptional repressor that binds to chromosomally integrated TAR DNA and represses HIV-1 transcription. In addition, this protein regulates alternate splicing of the CFTR gene. In particular, TDP-43 is a splicing factor binding to the intron8/exon9 junction of the CFTR gene and to the intron2/exon3 region of the apoA-II gene. A similar pseudogene is present on chromosome 20.
TDP-43 has been shown to bind both DNA and RNA and have multiple functions in transcriptional repression, pre-mRNA splicing and translational regulation. Recent work has characterized the transcriptome-wide binding sites revealing that thousands of RNAs are bound by TDP-43 in neurons.
TDP-43 was originally identified as a transcriptional repressor that binds to chromosomally integrated trans-activation response element (TAR) DNA and represses HIV-1 transcription. It was also reported to regulate alternate splicing of the CFTR gene and the apoA-II gene.
Podcasts:
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by 'N Sync
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by Tina Arena
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by Lil' B
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by Latent Anxiety
Dirty Pop
by: 'N SyncDirty pop, yo
B.T.
[Justin:]
Sick and tired of hearing
All these people talk about
What's the deal with this pop life?
And when is gonna fade out?
The thing you got to realize
What we doing is not a trend
We got the gift of melody
We gonna bring it till the end
(Come on now)
[JC:]
It doesn't matter
'Bout the car I drive or
What I wear around my neck
All that matters
Is that you recognize
That it's just about respect
It doesn't matter
About the clothes I wear
And where I go and why
All that matters
Is that you get hyped and
We'll do it to you every time
(Come on now)
[CHORUS:]
Do you ever wonder why
This music gets you high?
It takes you on a ride
Feel it when your body
Starts to rock
(Your body starts to rock)
Baby you can't stop
(You can't stop)
And the music's all you got
Come on now
This must be, pop
Dirty pop
Baby you can't stop
I know you
Like this dirty pop
This must be
[JC:]
Now, why you wanna try
To classify the type of thing
That we do
'Cause we're just fine
Doin what we like
Can we say the same for you?
Tired of feelin all
Around me animosity
Just worry about yours
'Cause I'ma get mine
Now people can't you see
[Justin:]
It doesn't matter
'Bout the car I drive or
The ice around my neck
All that matters
Is that you recognize
That it's just about respect (oh)
It doesn't matter
About the clothes I wear
And where I go and why
All that matters
Is that you get hyped and
We'll give it to you every time
(Come on)
Do you ever wonder why (Why?)
This music gets you high?
(Music gets you high)
It takes you on a ride
Feel it when your
Body starts to rock
(Your body starts to rock)
Baby you can't stop
(You can't stop)
And the music's all you got
Baby come on
This must be, pop
Man I'm tired of singing
Dirty, dirty, dirty pop
Dirty pop
Do you ever wonder?
[Echoes]
*NSYNC
(Oh)
Do you ever wonder why
(Every wonder why)
This music gets you high?
(Music gets you high)
It takes you on a ride
Feel it when your
Body starts to rock
(When your body
Starts to rock)
Baby you can't stop
(Baby don't stop)
And the music's all you got
Come on now
This must be
Do you ever wonder why
(Ever wonder)
This music gets you high?
(Music gets you high)
It takes you on a ride
Feel it when your
Body starts to rock
(When your body
Starts to rock)
Baby you can't stop
The music's all you got
This must be, pop