TAF
TAF may refer to:
- Australian First Tactical Air Force - South West Pacific Area
- Desert Air Force (later known as the First Tactical Air Force) - North Africa and later Italy
- RAF Second Tactical Air Force - Northern Europe
- RAF Third Tactical Air Force - South Asia
- Northwest African Tactical Air Force
TAF4
Transcription initiation factor TFIID subunit 4 is a protein that in humans is encoded by the TAF4 gene.
Function
Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes one of the larger subunits of TFIID that has been shown to potentiate transcriptional activation by retinoic acid, thyroid hormone and vitamin D3 receptors. In addition, this subunit interacts with the transcription factor CREB, which has a glutamine-rich activation domain, and binds to other proteins containing glutamine-rich regions. Aberrant binding to this subunit by proteins with expanded polyglutamine regions has been suggested as one of the pathogenetic mechanisms underlying a group of neurodegenerative disorders referred to as polyglutamine diseases.
TAF1
Transcription initiation factor TFIID subunit 1, also known as transcription initiation factor TFIID 250 kDa subunit (TAFII-250) or TBP-associated factor 250 kDa (p250), is a protein that in humans is encoded by the TAF1 gene.
Function
Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is the basal transcription factor TFIID, which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes the largest subunit of TFIID. This subunit binds to core promoter sequences encompassing the transcription start site. It also binds to activators and other transcriptional regulators, and these interactions affect the rate of transcription initiation. This subunit contains two independent protein kinase domains at the N and C-terminals, but also possesses acetyltransferase activity and can act as a ubiquitin-activating/conjugating enzyme. Two transcripts encoding different isoforms have been identified for this gene.
Podcasts:
Taf
ALBUMS
- Un poing c'est tout released: 2013
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Jurisdiction Of Love
by: DevoSOMEONE SAID THAT
NO ONE KNOWS WHAT
GOES ON INSIDE
SOMEONE IN LOVE
STRANGE AS IT SEEMS
IT MAKES THEM DO THINGS
IN THEIR RIGHT MINDS
WOULD NEVER THINK OF
PEOPLE GET AWAY WITH THINGS
THEY DON'T DESERVE
A JURISDICTION OF LOVE
ENOUGH'S NOT ENOUGH
WHEN LOVE GETS ROUGH
THE JURISDICTION OF LOVE
OFF THEIR WALLS
JUST LIKE NIAGARA FALLS
LOGICAL THOUGHT
IS NO COMFORT
IT ONLY MAKES THE
MATTER SEEM WORSE
MIGHT EQUALS RIGHT
IN CONCUBIAL FIGHT
THE JURISDICTION OF LOVE
LOVE EQUALS WAR
I DON'T LIKE IT NO MORE
THE JURISDICTION OF LOVE
PEOPLE GET AWAY WITH THINGS
THEY DON'T DESERVE
A JURISDICTION OF LOVE
WHEN LOVE TURNS THE CRANK
IT DEMANDS CARTE BLANCHE
Latest News for: taf
Rhondda Cynon Taf Council Celebrates International Women's Day 2025 (Rhondda Cynon Taff County Borough Council)
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