Leukocyte extravasation
Leukocyte extravasation, less commonly called diapedesis, is the movement of leukocytes out of the circulatory system and towards the site of tissue damage or infection. This process forms part of the innate immune response, involving the recruitment of non-specific leukocytes. Monocytes also use this process in the absence of infection or tissue damage during their development into macrophages.
Overview
Leukocyte extravasation occurs mainly in post-capillary venules, where haemodynamic shear forces are minimised. This process can be understood in several steps, outlined below as "chemoattraction", "rolling adhesion", "tight adhesion" and "(endothelial) transmigration". It has been demonstrated that leukocyte recruitment is halted whenever any of these steps is suppressed.
White blood cells (leukocytes) perform most of their functions in tissues. Functions include phagocytosis of foreign particles, production of antibodies, secretion of inflammatory response triggers (histamine and heparin), and neutralization of histamine. In general, leukocytes are involved in the defense of an organism and protect it from disease by promoting or inhibiting inflammatory responses. Leukocytes use the blood as a transport medium to reach the tissues of the body. Here is a brief summary of each of the four steps currently thought to be involved in leukocyte extravasation:
Rolling (metalworking)
In metalworking, rolling is a metal forming process in which metal stock is passed through one or more pairs of rolls to reduce the thickness and to make the thickness uniform. The concept is similar to the rolling of dough. Rolling is classified according to the temperature of the metal rolled. If the temperature of the metal is above its recrystallization temperature, then the process is known as hot rolling. If the temperature of the metal is below its recrystallization temperature, the process is known as cold rolling. In terms of usage, hot rolling processes more tonnage than any other manufacturing process, and cold rolling processes the most tonnage out of all cold working processes.Roll stands holding pairs of rolls are grouped together into rolling mills that can quickly process metal, typically steel, into products such as structural steel (I-beams, angle stock, channel stock, and so on), bar stock, and rails. Most steel mills have rolling mill divisions that convert the semi-finished casting products into finished products.
Rolling (video game)
Rolling is an extreme sports video game released in 2003 for PlayStation 2 and Xbox. Subsequent Game Boy Advance and Gamecube versions were cancelled due to a declining interest in extreme sports titles. To date, it is one of the few other games depicting aggressive inline skating apart from Aggressive Inline and the Jet Set Radio series. It was originally developed by the now defunct Rage Software, who were aiming to create a more authentic recreation of the sport (the box art claims the game features 250 tricks), unlike Aggressive Inline which focused on exaggerated, fantasy-themed levels and high scoring, fairly unrealistic tricks.
Players can choose to skate as one of the twenty available skaters (excluding the twenty first, and hidden, skater) and work their way through a progressively difficult "career mode" featuring a total of fourteen levels, gaining reputation, sponsorship deals, as well as unlocking new 'tricks' and videos of the pro skaters.
Development
Rage Software announced the game just prior to the May 2001 E3 show, with the working title of Cesar and Fabiola's Inline Skate. Rage continued with development of the game throughout 2002, releasing more previews and screenshots of the game as it came to fruition under the new title of Rolling (Sk8). However, Rage Software began to suffer financial problems that year, and were forced to close in January 2003, before the game was released.
List of minor Buffy the Vampire Slayer characters
Buffy the Vampire Slayer is an American franchise which spans several media and genres. It began in 1992 with the film Buffy the Vampire Slayer, written by Joss Whedon and directed by Fran Rubel Kuzui, and was resurrected as the television series, Buffy the Vampire Slayer in 1997. The show's popularity caused it to spawn a multitude of Expanded Universe tie-in material such as comic books, novels, and video games, as well as a spin-off program entitled Angel. In 2007, four years after the television series' seventh and final season, Buffy the Vampire Slayer was officially continued in the comic book Season Eight. The following is a list of minor recurring characters who appear in the franchise.
A
Aluwyn
(a.k.a. Saga Vasuki)
Amanda
Amanda is a Potential Slayer who appears in Season Seven, played by Sarah Hagan. A Sunnydale High student and member of the swing choir, she first appears in the episode "Help" as part of the seemingly-random stream of students showing up at Buffy's guidance office. Amanda was sent to Buffy for beating up another student who was picking on her. In the later episode "Potential", it is revealed that Amanda is in fact a Potential Slayer, and she aptly slays a vampire who threatens her and Dawn. Afterwards, Amanda moves into the Summers' residence, where she trains and becomes friends with her fellow Potentials. In the final episode of the show, "Chosen", Amanda is activated as a Slayer along with the other Potentials and battles against an army of Turok-Han vampires. She is last seen falling to the ground dead after her neck was snapped by a Turok-Han. She was the first Potential to kill a vampire and the first one to kill a Turok-Han.
Sweet (Ken Mellons album)
Sweet is the fourth studio album released by American country music artist Ken Mellons. Released in 2004, it contains the song "Paint Me a Birmingham", which was also recorded by Tracy Lawrence and released as a single. Mellons's rendition was also released shortly before Lawrence's. "Smack Dab" was previously recorded by George Jones on his 1998 album It Don't Get Any Better Than This.
Track listing
Colleen (rowboat)
Colleen was a rowboat used on Okanagan Lake in British Columbia, Canada in the late 1800s and early 1900s. She belonged to the Reverend Thomas Greene and served many early settlers and pioneers of the Okanagan, including W. D. Walker and Thomas Ellis, the earliest European settler in Penticton, British Columbia.
See Also
References
Podcasts:
