Ago

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Argonaute

The Argonaute protein family plays a central role in RNA silencing processes, as essential catalytic components of the RNA-induced silencing complex (RISC). RISC complex is responsible for the gene silencing phenomenon known as RNA interference (RNAi). Argonaute proteins bind different classes of small non-coding RNAs, including microRNAs (miRNAs), small interfering RNAs (siRNAs) and Piwi-interacting RNAs (piRNAs). Small RNAs guide Argonaute proteins to their specific targets through sequence complementarity (base pairing), which then leads to mRNA cleavage or translation inhibition.

Discovery

The RNA interference (RNAi) was first reported in 1995 by Guo and Kemphues, and similar pathways collectively referred to as RNA silencing were discovered in plants and fungi. The beginning of people’s understanding of the mechanism of RNA silencing began only in 1998 with the experiments of Fire and colleagues demonstrating that double-stranded RNA triggered RNAi. RNA silencing pathways process long RNAs into small RNAs that direct the repression of transcription or translation of nucleic acid targets with sequence corresponding to the small RNAs. These single-stranded RNAs, referred to as guide strands, are incorporated into RNA silencing effectors complexes such as the RNA-induced silencing complex (RISC). These RNA silencing effector complexes contain Argonaute family proteins.

Sunlight

Sunlight is a portion of the electromagnetic radiation given off by the Sun, in particular infrared, visible, and ultraviolet light. On Earth, sunlight is filtered through Earth's atmosphere, and is obvious as daylight when the Sun is above the horizon. When the direct solar radiation is not blocked by clouds, it is experienced as sunshine, a combination of bright light and radiant heat. When it is blocked by the clouds or reflects off other objects, it is experienced as diffused light. The World Meteorological Organization uses the term "sunshine duration" to mean the cumulative time during which an area receives direct irradiance from the Sun of at least 120 watts per square meter.

The ultraviolet radiation in sunlight has both positive and negative health effects, as it is both a principal source of vitamin D₃ and a mutagen.

Summary

Researchers may record sunlight using a sunshine recorder, pyranometer, or pyrheliometer.

Sunlight takes about 8.3 minutes to reach Earth from the surface of the Sun. A photon starting at the centre of the Sun and changing direction every time it encounters a charged particle would take between 10,000 and 170,000 years to get to the surface.

Sunlight (album)

Sunlight is a June 1978 jazz-funk, fusion album by keyboardist Herbie Hancock. It features Hancock's vocals through a vocoder as well as performances by drummer Tony Williams and bassist Jaco Pastorius. This was when Hancock began heading towards a more mainstream Smooth Jazz/R&B fusion, similar to fellow Jazz-Fusion pianist Patrice Rushen. This would last until his 1982 album Lite Me Up.

The album produced a single entitled "I Thought It Was You" which was mildly received at the time by UK jazz listeners. As a whole the album tends to lay more toward funk than a jazz record, and is reminiscent of much of the electro-funk of the time. This release marks the beginning of the 1980s electro-era style that was more refined in Herbie's later albums such as Future Shock and Sound-System.

Track listing

All tracks composed by Herbie Hancock, except where indicated.

Side one

Sunlight (cleaning product)

Sunlight is a brand of household soap originally produced by the British company Lever Brothers in 1884. It was the world's first packaged, branded laundry soap. Designed for washing clothes and general household use, the success of the product led to the name for the company's village for its workers, Port Sunlight. The soap formula was invented by a Bolton chemist named William Hough Watson, who also became an early business partner. Watson's process created a new soap, using glycerin and vegetable oils such as palm oil rather than tallow (animal fats).William Lever and his brother James Darcy Lever invested in Watson's soap invention and its initial success came from offering bars of cut, wrapped, and branded soap in his father's grocery shop. Prior to this, commercially made soap was bought in long bars, an early labour-saving device for the housewife.

Sunlight was eventually supplanted by modern products made from synthetically produced detergents rather than naturally derived soaps.