The American Sugar Refining Company (ASR) was the largest American business unit in the sugar refining industry in the early 1900s. It had interests in Puerto Rico and other Caribbean locations, and operated one of the world's largest sugar refineries located in Brooklyn, New York.
The ASR was incorporated in the state of New Jersey on January 10, 1891, with $50 million in capital. By 1907, it owned or controlled 98% of the sugar processing capacity in the United States and was known as the Sugar Trust.
The United States Supreme Court declared in United States v. E. C. Knight Company that its purchase of the stock of competitors was not a combination in restraint of trade. By 1901, the company had $90 million in capital. The company became known as Domino Sugar in 1900.
The combination expanded horizontally for about twenty years as new competitors arose; later it expanded vertically, undertaking the production of cane sugar and raw sugar in Cuba and acquiring lumber interests. The company was investigated by the Industrial Commission in 1900 and by a special congressional committee in 1911–1912.