Submarine

A submarine is a watercraft capable of independent operation underwater. It differs from a submersible, which has more limited underwater capability. The term most commonly refers to a large, crewed, autonomous vessel. It is also sometimes used historically or colloquially to refer to remotely operated vehicles and robots, as well as medium-sized or smaller vessels, such as the midget submarine and the wet sub. Used as an adjective in phrases such as submarine cable, "submarine" means "under the sea". The noun submarine evolved as a shortened form of submarine boat (and is often further shortened to sub). For reasons of naval tradition, submarines are usually referred to as "boats" rather than as "ships", regardless of their size.

Although experimental submarines had been built before, submarine design took off during the 19th century, and they were adopted by several navies. Submarines were first widely used during World War I (1914–1918), and now figure in many navies large and small. Military usage includes attacking enemy surface ships (merchant and military), submarines, aircraft carrier protection, blockade running, ballistic missile submarines as part of a nuclear strike force, reconnaissance, conventional land attack (for example using a cruise missile), and covert insertion of special forces. Civilian uses for submarines include marine science, salvage, exploration and facility inspection/maintenance. Submarines can also be modified to perform more specialized functions such as search-and-rescue missions or undersea cable repair. Submarines are also used in tourism, and for undersea archaeology.

Submarine (baseball)

In baseball, a submarine pitch is one in which the ball is released underhand, and often just above the ground, with the torso bent at a right angle and shoulders tilted so severely that they rotate around a nearly horizontal axis. (This is in stark contrast to an underhand pitch in softball in which the torso remains upright, the shoulders are level, and the hips do not rotate.)

The "upside down" release of the submariner causes balls to move differently from pitches generated by other arm slots. Gravity plays a significant role, for the submariner’s ball must be thrown considerably above the strike zone, after which it drops rapidly back through. The sinking motion of the submariner’s fastball is enhanced by forward rotation, in contradistinction to the overhand pitcher’s hopping backspin.

Submarine pitches are often the toughest for same-side batters to hit (i.e., a right-handed submarine pitcher is the more difficult for a right-handed batter to hit, and likewise for left-handed pitchers and batters). This is because the submariner’s spin is not perfectly level; the ball rotates forward and toward the pitching arm side, jamming same-sided hitters at the last moment, even as the ball drops rapidly through the zone.

Marine geology

Marine geology or geological oceanography is the study of the history and structure of the ocean floor. It involves geophysical, geochemical, sedimentological and paleontological investigations of the ocean floor and coastal zone. Marine geology has strong ties to physical oceanography.

Marine geological studies were of extreme importance in providing the critical evidence for sea floor spreading and plate tectonics in the years following World War II. The deep ocean floor is the last essentially unexplored frontier and detailed mapping in support of both military (submarine) objectives and economic (petroleum and metal mining) objectives drives the research.

Overview

The Ring of Fire around the Pacific Ocean with its attendant intense volcanism and seismic activity poses a major threat for disastrous earthquakes, tsunamis and volcanic eruptions. Any early warning systems for these disastrous events will require a more detailed understanding of marine geology of coastal and island arc environments.

Human Exploitation and Organised Crime Command

The Human Exploitation and Organised Crime Command (SCD9) is a branch of the Specialist Crime Directorate within London's Metropolitan Police Service. The SCD9 is primarily tasked with investigating human trafficking, and also has responsibility for policing prostitution, obscene publications, nightclubs, vice, casino fraud, money laundering and identity fraud.

Formation

On 29 October 2009, the Metropolitan Police Authority (MPA) received a report on the MPS review into investigation of human trafficking. The report profiled the units investigating these crimes: the clubs and vice unit (CO14), then part of Central Operations; and the Human Trafficking Team (HTT), then part of Operation Maxim with a remit to investigate organised immigration crime.

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Device file

In Unix-like operating systems, a device file or special file is an interface for a device driver that appears in a file system as if it were an ordinary file. There are also special files in MS-DOS, OS/2, and Microsoft Windows. They allow software to interact with a device driver using standard input/output system calls, which simplifies many tasks and unifies user-space I/O mechanisms.

Device files often provide simple interfaces to peripheral devices, such as printers and serial ports. But they can also be used to access specific resources on those devices, such as disk partitions. Finally, device files are useful for accessing system resources that have no connection with any actual device such as data sinks and random number generators.

MS-DOS borrowed the concept of special files from Unix, but renamed them devices. Because early versions of MS-DOS did not support a directory hierarchy, devices were distinguished from regular files by making their names reserved words. This means that certain file names were reserved for devices, and should not be used to name new files or directories. The reserved names themselves were chosen to be compatible with "special files" handling of PIP command in CP/M. There were two kinds of devices in MS-DOS: Block Devices (used for disk drives) and Character Devices (generally all other devices, including COM and PRN devices). PIPE, MAILSLOT, and MUP are other standard Windows devices.

CD14

CD14 (cluster of differentiation 14), also known as CD14, is a human gene.

The protein encoded by this gene is a component of the innate immune system. CD14 exists in two forms, one anchored to the membrane by a glycosylphosphatidylinositol tail (mCD14), the other a soluble form (sCD14). Soluble CD14 either appears after shedding of mCD14 (48 kDa) or is directly secreted from intracellular vesicles (56 kDa).

The x-ray crystal structure of human CD14 (4GLP.pdb) reveals a monomeric, bent solenoid structure containing a hydrophobic amino-terminal pocket.

CD14 was the first described pattern recognition receptor.

Function

CD14 acts as a co-receptor (along with the Toll-like receptor TLR 4 and MD-2) for the detection of bacterial lipopolysaccharide (LPS). CD14 can bind LPS only in the presence of lipopolysaccharide-binding protein (LBP). Although LPS is considered its main ligand, CD14 also recognizes other pathogen-associated molecular patterns such as lipoteichoic acid.

Tissue distribution

CD14 is expressed mainly by macrophages and (at 10-times lesser extent) by neutrophils. It is also expressed by dendritic cells. The soluble form of the receptor (sCD14) is secreted by the liver and monocytes and is sufficient in low concentrations to confer LPS-responsiveness to cells not expressing CD14. mCD14 and sCD14 are also present on enterocytes. sCD14 is also present in human milk, where it is believed to regulate microbial growth in the infant gut.