DPM

DPM is a three-letter initialism, and may refer to:

Science and technology

Computing

Business

People

DPM1

Dolichol-phosphate mannosyltransferase is an enzyme that in humans is encoded by the DPM1 gene.

Function

Dolichol-phosphate mannose (Dol-P-Man) serves as a donor of mannosyl residues on the lumenal side of the endoplasmic reticulum (ER). Lack of Dol-P-Man results in defective surface expression of GPI-anchored proteins. Dol-P-Man is synthesized from GDP-mannose and dolichol-phosphate on the cytosolic side of the ER by the enzyme dolichyl-phosphate mannosyltransferase. Human DPM1 lacks a carboxy-terminal transmembrane domain and signal sequence and is regulated by DPM2.

Model organisms

Model organisms have been used in the study of DPM1 function. A conditional knockout mouse line called Dpm1^{tm1b(KOMP)Wtsi} was generated at the Wellcome Trust Sanger Institute. Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion. Additional screens performed: - In-depth immunological phenotyping

References

Further reading

External links

DPM2

Dolichol phosphate-mannose biosynthesis regulatory protein is a protein that in humans is encoded by the DPM2 gene.

Function

Dolichol-phosphate mannose (Dol-P-Man) serves as a donor of mannosyl residues on the lumenal side of the endoplasmic reticulum (ER). Lack of Dol-P-Man results in defective surface expression of GPI-anchored proteins, defective N-linked glycosylation and deficient O-mannosylation of α-dystroglycan. Dol-P-Man is synthesized from GDP-mannose and dolichol-phosphate on the cytosolic side of the ER by the enzyme dolichyl-phosphate mannosyltransferase. The protein encoded by this gene is a hydrophobic protein that contains 2 predicted transmembrane domains and a putative ER localization signal near the C-terminus. This protein associates with DPM1 in vivo and is required for the ER localization and stable expression of DPM1 and also enhances the binding of dolichol-phosphate to DPM1.

Clinical significance

Mutations in this gene are associated with congenital disorder of glycosylation.

Stop

Stop may refer to:

Film

Music

Albums

Songs

Octagrammic prism

In geometry, the octagrammic prism is one of an infinite set of nonconvex prisms formed by square sides and two regular star polygon caps, in this case two octagrams.

Stop (Sibel Redžep song)

Stop! is a song written by Mikaela Stenström och Dimitri Stassos, and performed by Sibel Redžep at Melodifestivalen 2010. The song participated in the semifinal inside the Malmö Arena, but didn't make it further. It as also released as a single the same year. and peaked at 27th position at the Swedish singles chart.

Chart positions

References