Ago

Ago or AGO may refer to:

People

Places

Other uses

Argonaute

The Argonaute protein family plays a central role in RNA silencing processes, as essential catalytic components of the RNA-induced silencing complex (RISC). RISC complex is responsible for the gene silencing phenomenon known as RNA interference (RNAi). Argonaute proteins bind different classes of small non-coding RNAs, including microRNAs (miRNAs), small interfering RNAs (siRNAs) and Piwi-interacting RNAs (piRNAs). Small RNAs guide Argonaute proteins to their specific targets through sequence complementarity (base pairing), which then leads to mRNA cleavage or translation inhibition.

Discovery

The RNA interference (RNAi) was first reported in 1995 by Guo and Kemphues, and similar pathways collectively referred to as RNA silencing were discovered in plants and fungi. The beginning of people’s understanding of the mechanism of RNA silencing began only in 1998 with the experiments of Fire and colleagues demonstrating that double-stranded RNA triggered RNAi. RNA silencing pathways process long RNAs into small RNAs that direct the repression of transcription or translation of nucleic acid targets with sequence corresponding to the small RNAs. These single-stranded RNAs, referred to as guide strands, are incorporated into RNA silencing effectors complexes such as the RNA-induced silencing complex (RISC). These RNA silencing effector complexes contain Argonaute family proteins.

Stage

Stage or stages is an abstract object often associated with either theater and scene or point of progress.

It may also refer to:

Acting

Music

Stage (film)

Stage is a 1951 Bollywood film starring Dev Anand and Kuldip Kaur in lead roles.

Music

References

External Links

Stage (hydrology)

In hydrology, stage refers to the water level in a river or stream with respect to a chosen reference height. Stage is important because direct measurements of river discharge are very difficult while water surface elevation measurements are comparatively easy. In order to convert stage into discharge, scientists can use a combination of tracer studies, observations of high water marks, numerical modeling, and/or satellite or aerial photography. The relationship between stage and discharge is called a rating curve.