| Synovial sarcoma translocation, chromosome 18 | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||||||
| Symbols | SS18; SSXT; SYT | ||||||||||||
| External IDs | OMIM: 600192 MGI: 107708 HomoloGene: 38080 GeneCards: SS18 Gene | ||||||||||||
|
|||||||||||||
| RNA expression pattern | |||||||||||||
 |
|||||||||||||
 |
|||||||||||||
 |
|||||||||||||
| More reference expression data | |||||||||||||
| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 6760 | 268996 | |||||||||||
| Ensembl | ENSG00000141380 | ENSMUSG00000037013 | |||||||||||
| UniProt | Q15532 | Q62280 | |||||||||||
| RefSeq (mRNA) | NM_001007559.1 | NM_001161369.1 | |||||||||||
| RefSeq (protein) | NP_001007560.1 | NP_001154841.1 | |||||||||||
| Location (UCSC) | Chr 18: 23.6 – 23.67 Mb |
Chr 18: 14.78 – 14.84 Mb |
|||||||||||
| PubMed search | [1] | [2] | |||||||||||
Protein SSXT is a protein that in humans is encoded by the SS18 gene.[1][2][3][4]
Interactions [link]
SS18 has been shown to interact with MLLT10,[5] EP300,[6] SMARCB1[7] and SMARCA2.[8]
References [link]
- ^ Shipley JM, Clark J, Crew AJ, Birdsall S, Rocques PJ, Gill S, Chelly J, Monaco AP et al. (May 1994). "The t(X;18)(p11.2;q11.2) translocation found in human synovial sarcomas involves two distinct loci on the X chromosome". Oncogene 9 (5): 1447–53. PMID 8152806.
- ^ Clark J, Rocques PJ, Crew AJ, Gill S, Shipley J, Chan AM, Gusterson BA, Cooper CS (Dec 1994). "Identification of novel genes, SYT and SSX, involved in the t(X;18)(p11.2;q11.2) translocation found in human synovial sarcoma". Nat Genet 7 (4): 502–8. DOI:10.1038/ng0894-502. PMID 7951320.
- ^ de Bruijn DR, Geurts van Kessel A (February 2006). "Common origin of the human synovial sarcoma associated SS18 and SS18L1 gene loci". Cytogenet Genome Res 112 (3–4): 222–6. DOI:10.1159/000089874. PMID 16484776.
- ^ "Entrez Gene: SS18 synovial sarcoma translocation, chromosome 18". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6760.
- ^ de Bruijn, D R; dos Santos N R, Thijssen J, Balemans M, Debernardi S, Linder B, Young B D, Geurts van Kessel A (May 2001). "The synovial sarcoma associated protein SYT interacts with the acute leukemia associated protein AF10". Oncogene (England) 20 (25): 3281–9. DOI:10.1038/sj.onc.1204419. ISSN 0950-9232. PMID 11423977.
- ^ Eid, J E; Kung A L, Scully R, Livingston D M (September 2000). "p300 interacts with the nuclear proto-oncoprotein SYT as part of the active control of cell adhesion". Cell (UNITED STATES) 102 (6): 839–48. DOI:10.1016/S0092-8674(00)00072-6. ISSN 0092-8674. PMID 11030627.
- ^ Kato, Hiroyuki; Tjernberg Agneta, Zhang Wenzhu, Krutchinsky Andrew N, An Woojin, Takeuchi Tamotsu, Ohtsuki Yuji, Sugano Sumio, de Bruijn Diederik R, Chait Brian T, Roeder Robert G (February 2002). "SYT associates with human SNF/SWI complexes and the C-terminal region of its fusion partner SSX1 targets histones". J. Biol. Chem. (United States) 277 (7): 5498–505. DOI:10.1074/jbc.M108702200. ISSN 0021-9258. PMID 11734557.
- ^ Perani, Michela; Ingram Catherine J E, Cooper Colin S, Garrett Michelle D, Goodwin Graham H (November 2003). "Conserved SNH domain of the proto-oncoprotein SYT interacts with components of the human chromatin remodelling complexes, while the QPGY repeat domain forms homo-oligomers". Oncogene (England) 22 (50): 8156–67. DOI:10.1038/sj.onc.1207031. ISSN 0950-9232. PMID 14603256.
Further reading [link]
- Fligman I, Lonardo F, Jhanwar SC et al. (1996). "Molecular diagnosis of synovial sarcoma and characterization of a variant SYT-SSX2 fusion transcript". Am. J. Pathol. 147 (6): 1592–9. PMC 1869933. PMID 7495284. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1869933.
- Brett D, Whitehouse S, Antonson P et al. (1998). "The SYT protein involved in the t(X;18) synovial sarcoma translocation is a transcriptional activator localised in nuclear bodies". Hum. Mol. Genet. 6 (9): 1559–64. DOI:10.1093/hmg/6.9.1559. PMID 9285794.
- Thaete C, Brett D, Monaghan P et al. (1999). "Functional domains of the SYT and SYT-SSX synovial sarcoma translocation proteins and co-localization with the SNF protein BRM in the nucleus". Hum. Mol. Genet. 8 (4): 585–91. DOI:10.1093/hmg/8.4.585. PMID 10072425.
- Eid JE, Kung AL, Scully R, Livingston DM (2000). "p300 interacts with the nuclear proto-oncoprotein SYT as part of the active control of cell adhesion". Cell 102 (6): 839–48. DOI:10.1016/S0092-8674(00)00072-6. PMID 11030627.
- Tamborini E, Agus V, Mezzelani A et al. (2001). "Identification of a novel spliced variant of the SYT gene expressed in normal tissues and in synovial sarcoma". Br. J. Cancer 84 (8): 1087–94. DOI:10.1054/bjoc.2000.1710. PMC 2363857. PMID 11308259. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2363857.
- Brodin B, Haslam K, Yang K et al. (2001). "Cloning and characterization of spliced fusion transcript variants of synovial sarcoma: SYT/SSX4, SYT/SSX4v, and SYT/SSX2v. Possible regulatory role of the fusion gene product in wild type SYT expression". Gene 268 (1–2): 173–82. DOI:10.1016/S0378-1119(01)00412-7. PMID 11368913.
- de Bruijn DR, dos Santos NR, Thijssen J et al. (2001). "The synovial sarcoma associated protein SYT interacts with the acute leukemia associated protein AF10". Oncogene 20 (25): 3281–9. DOI:10.1038/sj.onc.1204419. PMID 11423977.
- Suzuki H, Fukunishi Y, Kagawa I et al. (2001). "Protein–Protein Interaction Panel Using Mouse Full-Length cDNAs". Genome Res. 11 (10): 1758–65. DOI:10.1101/gr.180101. PMC 311163. PMID 11591653. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=311163.
- Kato H, Tjernberg A, Zhang W et al. (2002). "SYT associates with human SNF/SWI complexes and the C-terminal region of its fusion partner SSX1 targets histones". J. Biol. Chem. 277 (7): 5498–505. DOI:10.1074/jbc.M108702200. PMID 11734557.
- Yang K, Lui WO, Xie Y et al. (2002). "Co-existence of SYT-SSX1 and SYT-SSX2 fusions in synovial sarcomas". Oncogene 21 (26): 4181–90. DOI:10.1038/sj.onc.1205569. PMID 12037676.
- Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. DOI:10.1073/pnas.242603899. PMC 139241. PMID 12477932. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
- Imabayashi H, Mori T, Gojo S et al. (2003). "Redifferentiation of dedifferentiated chondrocytes and chondrogenesis of human bone marrow stromal cells via chondrosphere formation with expression profiling by large-scale cDNA analysis". Exp. Cell Res. 288 (1): 35–50. DOI:10.1016/S0014-4827(03)00130-7. PMID 12878157.
- Perani M, Ingram CJ, Cooper CS et al. (2003). "Conserved SNH domain of the proto-oncoprotein SYT interacts with components of the human chromatin remodelling complexes, while the QPGY repeat domain forms homo-oligomers". Oncogene 22 (50): 8156–67. DOI:10.1038/sj.onc.1207031. PMID 14603256.
- Gerhard DS, Wagner L, Feingold EA et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. DOI:10.1101/gr.2596504. PMC 528928. PMID 15489334. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.
- Iwasaki T, Koibuchi N, Chin WW (2005). "Synovial sarcoma translocation (SYT) encodes a nuclear receptor coactivator". Endocrinology 146 (9): 3892–9. DOI:10.1210/en.2004-1513. PMID 15919756.
- Fernebro J, Francis P, Edén P et al. (2006). "Gene expression profiles relate to SS18/SSX fusion type in synovial sarcoma". Int. J. Cancer 118 (5): 1165–72. DOI:10.1002/ijc.21475. PMID 16152617.
- Perani M, Antonson P, Hamoudi R et al. (2006). "The proto-oncoprotein SYT interacts with SYT-interacting protein/co-activator activator (SIP/CoAA), a human nuclear receptor co-activator with similarity to EWS and TLS/FUS family of proteins". J. Biol. Chem. 280 (52): 42863–76. DOI:10.1074/jbc.M502963200. PMID 16227627.
- Sun Y, Gao D, Liu Y et al. (2006). "IGF2 is critical for tumorigenesis by synovial sarcoma oncoprotein SYT-SSX1". Oncogene 25 (7): 1042–52. DOI:10.1038/sj.onc.1209143. PMID 16247461.
 |
This article on a gene on chromosome 18 is a stub. You can help Wikipedia by expanding it. |
https://wn.com/SS18
Podcasts:
PLAYLIST TIME:
-
by Zazie
-
by Zazie
-
by Zazie
-
by Zazie
-
by Zazie
-
by Zazie
-
by Zazie
-
by Zazie
-
by Zazie
-
by Zazie
-
by Zazie
-
by Zazie
-
by Zazie
-
by Zazie
-
by Zazie
-
by Zazie
-
by Zazie
-
by Zazie
-
by Zazie
-
by Zazie
-
by Zazie
-
by Zazie
-
by Zazie
-
by Zazie
-
by Zazie
-
by Zazie
-
by Zazie
-
by Zazie
-
by Zazie
-
by Zazie
-
by Zazie
-
by Zazie
-
by Zazie
-
by Zazie
-
by Zazie
-
by Zazie
-
by Zazie
-
by Zazie
-
by Zazie
-
by Zazie
-
by Zazie
-
by Zazie
-
by Zazie
-
by Zazie
-
by Zazie
-
by Zazie
-
by Zazie
-
by Zazie
-
by Zazie
Un Point C'est Toi
by: ZazieMets-toi tout nu, si t'es un homme.
Histoire de voir où nous en sommes.
Qu'on me donne un primate.
Sans cravate.
Un Zorro.
Sans rien sur le dos...
t'es bien plus beau comme ça.
Un point c'est tout.
Un point c'est toi.
Je t'aime comme ça.
Un point c'est tout.
Un point c'est toi.
Sans artifice.
Où est le vice...
enlève la tenue.
Si t'es un homme.
Qui peut le plus.
Peut le minimum.
Et comme ça.
Tu restes la faiblesse.
De mon for intérieur.
Et moi, maîtresse.
En ta demeure...
t'es bien plus mâle comme ça.
Un point c'est tout.
Un point c'est toi.
Je t'aime comme ça.
Un point c'est tout.
Un point c'est toi.
Sans dessus, ni dessous.
Et puis c'est tout.
Et c'est comme ça...
gageons que tes états sauvages.
Feront moins de ravages.
Que tes plumes de paon.
Quand toi Tarzan.
Moi j'aime.
Quand tu tiens d'Adam.
Moi je tiens à toi.
t'es bien plus beau comme ça.
Un point c'est tout.
Un point c'est toi...
Je t'aime comme ça.
Un point c'est tout.
Un point c'est toi.
Sans rien du tout.
Sans rien que toi.