SPRED1

Sprouty-related, EVH1 domain-containing protein 1 (Spred-1) is a protein that in humans is encoded by the SPRED1 gene located on chromosome 15q13.2 and has seven coding exons.

Function

Spred-1 is a member of the Sprouty family of proteins and is phosphorylated by tyrosine kinase in response to several growth factors. The encoded protein can act as a homodimer or as a heterodimer with SPRED2 to regulate activation of the MAP kinase cascade.

Clinical associations

Defects in this gene are a cause of neurofibromatosis type 1-like syndrome (NFLS).

Mutations in this gene are associated with

Mutations

The following mutations have been observed:

Jana Kramer

Jana Rae Kramer (born December 2, 1983) is an American actress and country music singer. She is best known for her role as Alex Dupre on the television series One Tree Hill. Kramer began a country music career in 2012 with the single "Why Ya Wanna" from her self-titled debut album for Elektra Records.

Early life

Kramer was born in Rochester Hills, Michigan, United States, to Nora and Martin Kramer. She is of German Chilean, Croatian and French ancestry. Jana has one brother Steve who is a police officer. Jana attended Rochester Adams High School. She speaks some German.

Career

2002–11: acting career and record deal

In 2002, Kramer made her acting debut in the low-budget independent horror film Dead/Undead. The following year Kramer guest appeared on All My Children, which marked Kramer's television debut. Kramer has since continued to appear in a number of television shows such as CSI: Crime Scene Investigation, Grey's Anatomy, Private Practice and CSI: NY. She has also had small supporting roles in films such as Click, Prom Night and Spring Breakdown.

Tennis scoring system

A tennis tournament is organized into matches between players (for singles tournaments) or teams of two players (for doubles tournaments). The matches of a tournament are grouped into rounds. In round 1, all players (or teams) are paired and play against each other in matches. The losers are said to leave, or be out. They no longer compete in the tournament (this is single elimination). The winners are again paired to play in the matches of the next round. The tournament continues until the quarterfinal round (having eight players or teams playing in pairs), then the semifinal round (having four players or teams playing in pairs), and finally the final round (having only two players or teams) are played. The winner of the final round is declared the winner of the entire tournament.

A tennis match is composed of points, games, and sets. A match is won when a player or a doubles team wins the majority of prescribed sets. Traditionally, matches are either a best of three sets or best of five sets format. The best of five set format is typically only played in the Men's singles or doubles matches at Majors and Davis Cup matches.

Love (Angels & Airwaves album)

Love is the third studio album by alternative rock band Angels & Airwaves. It was released on February 12, 2010 on Fuel TV, and on February 14 on Modlife. The album was released free of charge due to "corporate underwriting". A "special edition" hard copy version of the album was scheduled for release on March 22, 2011, along with a second disc containing new music from the band. This was announced at a Q & A for the movie, which stated that it would be pushed back to Fall of 2011.

Production

On January 12, 2010, the band released a promotional video entitled "C:\Transmission_Love", which contained a short preview of The Flight of Apollo.

Release and special editions

In May 2009, it was announced that the album would be released on Christmas Day. However, on July 19, 2009, DeLonge announced via Modlife that the album will not be released on Christmas Day as previously planned, and instead will be released on Valentine's Day. The album was released free of charge through Modlife on Valentine's Day 2010.

Solitaire (disambiguation)

Solitaire or patience is a genre of tabletop games, consisting of card games that can be played by a single player.

Solitaire may also refer to:

Games

Music

Albums

Songs

Film

Solitaire (Andy Williams album)

Solitaire is an album by American pop singer Andy Williams that was released in the fall of 1973 by Columbia Records.

The album made its first appearance on the Billboard 200 chart in the issue dated November 17, 1973, and remained on the album chart for 6 weeks, peaking at number 185. It entered the UK album chart the following month, on December 22, and stayed there for 26 weeks, during which time it made it all the way to number three. On January 1, 1974, the newly formed British Phonographic Industry awarded the album with Silver certification for sales of 60,000 units in the UK, and Gold certification from the BPI, for sales of 100,000 units, followed on January 1, 1975.

The first single from the album was the title track, which entered Billboard magazine's list of the 40 most popular Easy Listening songs of the week in the U.S. in the issue dated October 6, 1973, and stayed on the chart for nine weeks, peaking at number 23. Although the song did not make the magazine's Hot 100, it did make the top five in the UK, where it entered the singles chart two months later, on December 8, and reached number four during an 18-week stay. Williams's rerecording of another song from the album, "Remember", as a duet with his daughter Noelle resulted in another Easy Listening chart entry as of the January 5, 1974, issue that made it to number 30 over the course of seven weeks. A third song, "Getting over You", entered the UK singles chart four months later, on May 18, and lasted there five weeks, eventually getting to number 35.