Spinorphin
Spinorphin is an endogenous, non-classical opioid peptide of the hemorphin family first isolated from the bovine spinal cord (hence the prefix spin-) and acts as a regulator of the enkephalinases, a class of enzymes that break down endogenous the enkephalin peptides. It does so by inhibiting the enzymes aminopeptidase N (APN), dipeptidyl peptidase III (DPP3), angiotensin-converting enzyme (ACE), and neutral endopeptidase (NEP). Spinorphin is a heptapeptide and has the amino acid sequence Leu-Val-Val-Tyr-Pro-Trp-Thr (LVVYPWT). It has been observed to possess antinociceptive,antiallodynic, and anti-inflammatory properties. The mechanism of action of spinorphin has not been fully elucidated (i.e., how it acts to inhibit the enkephalinases), but it has been found to act as an antagonist of the P2X3 receptor, and as a weak partial agonist/antagonist of the FP1 receptor.
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by Nirvana
Sappy
by: NirvanaAnd if you save yourself
You will make him happy
He'll keep you in a jar
And you'll think you're happy
He'll give you breathing holes
And you'll think you're happy
He'll cover you with grass
And you'll think you're happy now
You're in a laundry room
You're in a laundry room
The clue that came to you, oh
And if you cut yourself
You will think you're happy
He'll keep you in a jar
Then you'll make him happy
He'll give you breathing holes
Then you'll think you're happy
He'll cover you with grass
Then you'll think you're happy now
You're in a laundry room
You're in a laundry room
The clue that came to you, oh
You're in a laundry room
You're in a laundry room
The clue that came to you, oh
And if you fool yourself
You will make him happy
He'll keep you in a jar
Then you'll think you're happy
He'll give you breathing holes
Then you will seem happy
You'll wallow in the shit
Then you'll think you're happy now
You're in a laundry room
You're in a laundry room
You're in a laundry room
The clue that came to you, oh