Klinik

Klinik, (sometimes called The Klinik), is an industrial music band from Belgium, originally formed around 1982 by electro-synthpop practitioner Marc Verhaeghen, who is the only constant member.

History

Marc Verhaeghen originally formed Klinik in the early-to-mid 1980s; the exact date varies depending on the source. The group is normally described as one of the most influential Belgian industrial bands in history.

In 1985, Verhaeghen joined forces with two other bands, Absolute Body Control (with Dirk Ivens and Eric van Wonterghem), and "The Maniacs" (Sandy Nys) to form one "super group" "Absolute Controlled Clinical Maniacs". This rather unwieldy name was soon dropped in favour of the shorter name "The Klinik". Nys soon left the band to form "Hybryds", followed in 1987 by van Wonterghem, leaving The Klinik as the "classic" duo of Dirk Ivens and Marc Verhaeghen.

The Klinik soon made a name for themselves with their cold and harsh EBM sound and their live shows, where both Ivens and Verhaeghen performed with their heads wrapped in gauze, wearing long black leather coats. Ivens' hissing vocals and minimalist lyrics were complemented by Verhaeghen's synthesizer skills and distorted trombone playing. This however, did not last forever; after Time, an album neither member was fully pleased with, musical differences became too great, and they decided to go their separate ways. In a 2013 interview, Ivens said the due were moving in different directions musically, and that compromise between only two members was challenging.

Hi-Riser (automobile)

Hi-Risers are a type of highly customized automobile, typically a traditional, full-size, body on frame, V8 powered, rear wheel drive American-built sedan modified by significantly increasing the ground clearance and adding large-diameter wheels with low-profile tires. Depending on the model and style of body, autos customized in this manner can be labeled "donk," "box," or "bubble."

Hi-risers originally grew out of the Dirty South subculture, but the trend has spread across the United States. Vehicles customized in the hi-riser style are distinguished by their oversized (even disproportionate) wheels, ranging from 20 inches to 30 inches or more in diameter (largest being 50 inch), as well as fanciful custom paint-jobs and expensive audio equipment. Suspension modifications similar to those employed on lifted pickup trucks are made to give adequate clearance for the large wheels. Often the suspension is modified so the front end sits slightly higher than the rear end, giving the car a swaggering appearance. Because of the exaggerated look gained from installing a lifted suspension and enormous wheels, donks are also known as "hi-risers" or "sky-scrapers."

Hyperrectangle

In geometry, an n-orthotope (also called a hyperrectangle or a box) is the generalization of a rectangle for higher dimensions, formally defined as the Cartesian product of intervals.

Types

A three-dimensional orthotope is also called a right rectangular prism, rectangular cuboid, or rectangular parallelepiped.

A special case of an n-orthotope, where all edges are equal length, is the n-cube.

By analogy, the term "hyperrectangle" or "box" refers to Cartesian products of orthogonal intervals of other kinds, such as ranges of keys in database theory or ranges of integers, rather than real numbers.

Dual polytope

The dual polytope of an n-orthotope has been variously called a rectangular n-orthoplex, rhombic n-fusil, or n-lozenge. It is constructed by 2n points located in the center of the orthotope rectangular faces.

An n-fusil's Schläfli symbol can be represented by a sum of n orthogonal line segments: { } + { } + ... + { }.

A 1-fusil is a line segment. A 2-fusil is a rhombus. Its plane cross selections in all pairs of axes are rhombi.

ALCO RSD-15

The ALCO RSD-15 was a diesel-electric locomotive of the road switcher type built by ALCO (the American Locomotive Company) of Schenectady, New York between August 1956 and June 1960, during which time 75 locomotives were produced. The RSD-15 was powered by an ALCO 251 16-cylinder four-cycle V-type prime mover rated at 2,400 horsepower (1.79 MW); it superseded the almost identical ALCO 244-engined RSD-7, and was catalogued alongside the similar but smaller 1,800 hp (1.34 MW) RSD-12, powered by a 12-cylinder 251-model V-type diesel engine.

The locomotive rode on a pair of three-axle Trimount trucks, in an AAR C-C wheel arrangement, with all axles powered by General Electric model 752 traction motors. These trucks have an asymmetrical axle spacing because of the positioning of the traction motors. The six-motor design allowed higher tractive effort at lower speeds than an otherwise similar four-motor design.

The RSD-15 could be ordered with either a high or low short hood; railfans dubbed the low short hood version "Alligators", on account of their unusually long low noses.

Vernakalant

Vernakalant (INN; codenamed RSD1235, proposed tradenames Kynapid and Brinavess) is an investigational drug under regulatory review for the acute conversion of atrial fibrillation. It was initially developed by Cardiome Pharma, and the intravenous formulation was bought for further development by Merck in April 2009. In September 2012, Merck terminated its agreements with Cardiome and has consequently returned all rights of the drug back to Cardiome.

On 11 December 2007, the Cardiovascular and Renal Drugs Advisory Committee of the US Food and Drug Administration (FDA) voted to recommend the approval of vernakalant, but in August 2008 the FDA judged that additional information was necessary for approval. The drug (under brand name Brinavess) was approved in Europe on 1 September 2010.

An oral formulation underwent Phase II clinical trials between 2005 and 2008.

Mechanism of action

Like other class III antiarrhythmics, vernakalant blocks atrial potassium channels, thereby prolonging repolarization. It differs from typical class III agents by blocking a certain type of potassium channel, the cardiac transient outward potassium current, with increased potency as the heart rate increases. This means that it is more effective at high heart rates, while other class III agents tend to lose effectiveness under these circumstances. It also slightly blocks the hERG potassium channel, leading to a prolonged QT interval. This may theoretically increase the risk of ventricular tachycardia, though this does not seem to be clinically relevant.