BNC210
BNC210 (also known as IW-4123 during its time licensed to Ironwood Pharmaceuticals) is an anxiolytic drug that acts via negative allosteric modulation of the α7-nicotinic acetylcholine receptor, by Bionomics Limited. It demonstrates clinically significant anxiety reduction in both animal models and in Phase I trials.
It appears to be devoid of significant sedation or memory-impairing side effects, as well as lacking addictive potential in rat discriminatory models.
Phase I trials have shown no serious side effects.
Bionomics previously licensed it to Ironwood Pharmaceuticals in January 2012, where it was known as IW-2143. In December 2012, IW-2143 begun undergoing phase I clinical trials in the United States, but in November 2014, was released back to Bionomics in a mutual agreement. Bionomics will now continue development and clinical testing, with Ironwood receiving a royalty for their work done.
As of April 2015, BNC210 is in phase II clinical trials.
See also
Zinc finger protein basonuclin-2
Zinc finger protein basonuclin-2 is a protein that in humans is encoded by the BNC2 gene. BCN2 has recently been shown to influence skin pigmentation levels in Europeans. Genomic region spanning the BCN2 gene has 60% Neanderthal DNA sequence.
References
Further reading
National Bank of Canada
The National Bank of Canada (French: Banque Nationale du Canada) is the sixth largest commercial bank in Canada. It is headquartered in Montreal, and has branches in most Canadian provinces and 2.4 million personal clients. National Bank is the largest bank in Quebec, and the second largest financial institution in the province, after Desjardins. National Bank's Institution Number is 006 and its SWIFT code is BNDCCAMM.
As at October 31, 2014, National Bank had a network of 452 branches and 933 Automated Teller Machines in Canada. It also had a number of representative offices, subsidiaries and partnerships in other countries, through which it serves Canadian and non-Canadian clients.
In 2011, National Bank was placed third in Bloomberg's list of the "The World’s Strongest Banks".
History
In 1859, francophone businessmen in Ontario and Quebec were keen to establish a bank under their local control, and persuade the provincial legislature to pass the act that created the Banque Nationale on May 4, 1859. Some members of the anglophone bourgeoisie participated in the Bank’s share capital, but francophones retained exclusive control and held all seats on the Board of Directors with Ulric-Joseph Tessier, lawyer and Member of the Legislative Assembly serving as Chairman of the bank.
Sorry
Sorry may refer to:
Events
Books
Film, TV and games
Music
Albums
Songs
Sorry (Easybeats song)
"Sorry" is a 1966 song and single by Australian rock group The Easybeats, which was written by band members George Young and Stevie Wright. It peaked at #1 on the Australian Go-Set's National Top 40 in mid November 1966. It remained at #1 on the Australian Charts for 2 weeks in November 1966.
Releases
In addition to its 7" single release in October 1966, the song was issued on an EP in September 1967, along with the tracks "Friday On My Mind", "Who'll Be the One" and "Made My Bed, Gonna Lie in It". It was also the lead track on the Easybeat's third and last LP Volume 3, which they recorded in Australia, prior to moving to England.
An adaptation by American alternative rock group The Three O'Clock appears on the album Sixteen Tambourines (1983) and has been featured in the live performances of the band in the 2013 tour. Bassist Michael Quercio introduces it as part of the Australian influence on the band.
Track listing
Parlophone Single Cat. A-8224
Una Healy
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Una Theresa Imogene Foden (née Healy; 10 October 1981) is an Irish singer-songwriter, musician, and a television presenter. She rose to fame in 2008 as a member of the 5 member English–Irish girl group The Saturdays, signed to Fascination and Polydor Records. The group have achieved substantial success with numerous top-ten hits as well as a hit number one single entitled 'What About Us'. In October 2014, it was confirmed that she would become a judge on The Voice of Ireland.
Early life
Foden was born in Thurles, to Anne, a nurse, and John Healy, a GP. She has a sister named Deirdre. She comes from a musical background, and is the niece of country singer Declan Nerney. She is a cousin of Irish athlete Paul Hession. At the age of 13, she gave up swimming (she was an All-Ireland champion swimmer at nine) and decided to teach herself to play using her mother's guitar and from then on began to write songs of her own.
Podcasts:
