Mothers against decapentaplegic homolog 3
Mothers against decapentaplegic homolog 3 also known as SMAD family member 3 or SMAD3 is a protein that in humans is encoded by the SMAD3 gene. SMAD3 is a member of the SMAD family of proteins. It mediates the signals from the transforming growth factor beta (TGF-β) superfamily ligands that regulate cell proliferation, differentiation and death. Based on its essential role in TGF beta signaling pathway, SMAD3 has been related with tumor growth in cancer development.
Gene
The human SMAD3 gene is located on chromosome 15 with location of the cytogenic band at 15q22.33 is composed of 9 exons over 129,339 base pairs. It is one of several human homologues of a gene that was originally discovered in the fruit fly Drosophila melanogaster.
The expression of SMAD3 has been related to the mitogen-activated protein kinase (MAPK/ERK pathway), particularly to the activity of mitogen-activated protein kinase kinase-1 (MEK1). Studies have demonstrated that inhibition of MEK1 activity inhibits SMAD3 expression in epithelial cells and smooth muscle cells, two cell types highly responsive to TGF-β1.
Podcasts:
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by Carman
Some - O - Dat
by: CarmanWell I got this friend named T.J. Clyde
Who sees this strength of God inside
So he says to me, "Hey, I want Some-O-Dat"
I say Clyde it's easy as one, two, three
You just say this simple prayer with me
He said, "Not me Bubba, but I still want Some-O-Dat"
OOh Some-O-Dat
Well I was sharing with this sales man Lyle
So he says with a million dollar smile
"Why that's interesting you know. Hey I'd like Some-O-Dat."
I said "Lyle you're gonna have to humble your pride and ask the Lord to come inside."
He said, "No-ho-ho-ho, but I still want Some-O-Dat."
Ooh Some-O-Dat
Well you can't find it
In astrology
That horoscope that you read is just a waste
You can't find it looking at the stars
Jupiter, the moon and Mars.
Cause you'll soon find that all you got was space.
Well my best friends Ray has got this niece
That sees within my eyes this peace
And yesterday she said
"I want Some-O-Dat"
Well I said "Hey Sugar, Now it's a breeze
Just talk with Jesus on your knees
She said, "I'm not the type but I still want Some-O-Dat"
Ooh they all want Some-O-Dat
Brother you can't find it
In a bottle
Or even when you pop a pill or two
You can't find it smoking dope or weed
Cause one fine day you're gonna see
That the dope that's being smoked my friend is you
Well if you're depressed
Then get used to it
Cause without Jesus
You have blew it
He's the only one who can give you Some-O-Dat
Why not try the Lord for goodness sake
You'll be happy as a dog with a T-bone steak