SMAC may refer to:
Sid Meier's Civilization: Beyond Earth is a turn-based strategy, 4X video game in the Civilization series developed by Firaxis Games, published by 2K Games and released for Microsoft Windows on October 24, 2014, the Mac App Store on November 27, 2014 and for Linux on December 18, 2014. A spiritual successor to Alpha Centauri, Beyond Earth shares much of that game's development team, as well as some concepts which were introduced in the 1999 title. The game's setting is unique to the Civilization series in that it takes place in the future, with mankind traveling through space and founding colonies on extraterrestrial planets after Earth becomes uninhabitable due to an undescribed disaster known as "the Great Mistake".
An expansion pack, titled Rising Tide, was released on October 9, 2015.
Beyond Earth is a turn-based strategy game played on a hexagonal-based grid, iterating the ideas and building upon the engine of its predecessor, Civilization V. Co-lead designer David McDonough described the relationship between the two games by saying "The bones of the experience are very much recognisably Civ. The idea of the cities, city-base progression, leaders, the passage of time, tile-based, turn-based, building improvements, technologies. A lot of them are very familiar themes to the Civ player."
Diablo homolog (DIABLO) is a mitochondrial protein that in humans is encoded by the DIABLO (direct IAP binding protein with low pI) gene on chromosome 12. DIABLO is also referred to as second mitochondria-derived activator of caspases or SMAC. This protein binds inhibitor of apoptosis proteins (IAPs), thus freeing caspases to activate apoptosis. Due to its proapoptotic function, SMAC is implicated in a broad spectrum of tumors, and small molecule SMAC mimetics have been developed to enhance current cancer treatments.
This gene encodes a 130 Å-long, arch-shaped homodimer protein. The full-length protein product spans 239 residues, 55 of which comprise the mitochondrial-targeting sequence (MTS) at its N-terminal. However, once the full-length protein is imported into the mitochondria, this sequence is excised to produce the 184-residue mature protein. This cleavage also exposes four residues at the N-terminal, Ala-Val-Pro-Ile (AVPI), which is the core of the IAP binding domain and crucial for inhibiting XIAP. Specifically, the tetrapeptide sequence binds the BIR3 domain of XIAP to form a stable complex between SMAC and XIAP. The homodimer structure also facilitates SMAC-XIAP binding via the BIR2 domain, though it does not form until the protein is released into the cytoplasm as a result of outer mitochondrial membrane permeabilization. Thus, monomeric SMAC mutants can still bind the BIR3 domain but not the BIR2 domain, which compromises the protein’s inhibitory function. Meanwhile, mutations within the AVPI sequence lead to loss of function, though SMAC may still be able to perform IAP binding-independent functions, such as inducing the ubiquitinylation of XIAP.
The sun peaked at noon
I watched it hoping it would rise
Just a little higher
And give me a guiding light
A guiding light
I must admit I felt some relief
When the sun began to sink
I mean who really wants to see
Things in blinding white
Blinding white
It grows dark
I feel my way home
Sleep
Sleep if you can sleep
Me I'll be staying up
Long into the night
Trying to prove wrong
All the statements I made
All the statements I just made
A guiding light
You were born in the middle of the night