PLCG1

Phospholipase C, gamma 1, also known as PLCG1, is a protein that in humans is encoded by the PLCG1 gene.

Function

The protein encoded by this gene catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of receptor-mediated tyrosine kinase activators. For example, when activated by SRC, the encoded protein causes the Ras guanine nucleotide exchange factor RASGRP1 to translocate to the Golgi apparatus, where it activates Ras. Also, this protein has been shown to be a major substrate for heparin-binding growth factor 1 (acidic fibroblast growth factor)-activated tyrosine kinase. The receptor protein tyrosine phosphatase PTPmu (PTPRM) is capable of dephosphorylating PLCG1. Two transcript variants encoding different isoforms have been found for this gene.

Has been shown to interact with CISH which negatively regulates it by targeting it for degradation. The deletion of Cish in effector T cells has been shown to augment TCR signaling and subsequent effector cytokine release, proliferation and survival. The adoptive transfer of tumor-specific effector T cells knocked out or knocked down for CISH resulted in a significant increase in functional avidity and long-term tumor immunity. There are no changes in activity or phosphorylation of Cish's purported target, STAT5 in either the presence or absence of Cish.

Phosphoinositide phospholipase C

Phosphoinositide phospholipase C (PLC) (EC 3.1.4.11, triphosphoinositide phosphodiesterase, phosphoinositidase C, 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase, monophosphatidylinositol phosphodiesterase, phosphatidylinositol phospholipase C, PI-PLC, 1-phosphatidyl-D-myo-inositol-4,5-bisphosphate inositoltrisphosphohydrolase) is a family of eukaryotic intracellular enzymes that play an important role in signal transduction processes. These enzymes belong to a larger superfamily of Phospholipase C. Other families of phospholipase C enzymes have been identified in bacteria and trypanosomes. Phospholipases C are phosphodiesterases.

Phospholipase Cs participate in phosphatidylinositol 4,5-bisphosphate (PIP₂) metabolism and lipid signaling pathways in a calcium-dependent manner. At present, the family consists of six sub-families comprising a total of 13 separate isoforms that differ in their mode of activation, expression levels, catalytic regulation, cellular localization, membrane binding avidity and tissue distribution. All are capable of catalyzing the hydrolysis of PIP₂ into two important second messenger molecules, which go on to alter cell responses such as proliferation, differentiation, apoptosis, cytoskeleton remodeling, vesicular trafficking, ion channel conductance, endocrine function and neurotransmission.

Sky

The sky (or celestial dome) is everything that lies above the surface of the Earth, including the atmosphere and outer space.

In the field of astronomy, the sky is also called the celestial sphere. This is viewed from Earth's surface as an imaginary dome where the sun, stars, planets, and the moon are seen to be traveling. The celestial sphere is conventionally divided into regions called constellations. Usually, the term sky is used informally as the point of view from the Earth's surface; however, the meaning and usage can vary. In some cases, such as in discussing the weather, the sky refers to only the lower, more dense portions of the atmosphere.

During daylight, the sky appears to be blue because air scatters blue sunlight more than it scatters red. At night, the sky appears to be a mostly dark surface or region scattered with stars. During the day, the Sun can be seen in the sky unless obscured by clouds. In the night sky (and to some extent during the day) the moon, planets and stars are visible in the sky. Some of the natural phenomena seen in the sky are clouds, rainbows, and aurorae. Lightning and precipitation can also be seen in the sky during storms. Birds, insects, aircraft, and kites are often considered to fly in the sky. Due to human activities, smog during the day and light pollution during the night are often seen above large cities.

Sky (building)

Sky (also known as 605 West 42nd Street) is a mixed-use building in Midtown Manhattan developed by the Moinian Group. The building was originally known as "Atelier II" due to its proximity to another Moinian rental, Atelier. The building contains residences and retail space. The building is one of two major developments by Moinian in the Special Hudson Yards District, the other being 3 Hudson Boulevard. At 656 ft., is the 59th tallest building in New York City.

History and construction

The Moinian Group purchased the site in 2005. It originally held a gas station and a parking facility. The project first broke ground in 2008, but construction was stalled due to the recession from 2009 until 2012, and the project was dubbed, like several nearby developments, a "zombie project" because Moinan retained ownership of the site but did not continue development. Activity resumed with a redesign by David Rockwell, replacing the original by Costas Kondylis. Construction began again in 2013, and was completed by the end of 2015.Tishman Realty & Construction was the firm responsible for the construction of the building.

Sky blue

Sky blue is the name of a color that resembles the color of the sky at noon. The entry for "sky-blue" in Murray's New English Dictionary (1919) reports a first sighting of the term in the article on "silver" in Ephraim Chambers's Cyclopaedia of 1728. However, many writers had used the term "sky blue" to name a color before Chambers. For example, we find "sky blue" in A Collection of Voyages and Travels (London: Awnsham and John Churchill, 1704), vol. 2, p. 322, where John Nieuhoff describes certain flowers: "they are of a lovely sky blue colour, and yellow in the middle". The sense of this color may have been first used in 1585 in a book by Nicolas De Nicolay where he stated "the tulbant of the merchant must be skie coloured".

Displayed at right is the web colour sky blue.

Variations of sky blue

Celeste

Celeste (pronounced che-les-te in Italian se-lest in English) is the colloquial name for the pale turquoise blue colour associated with Italian bicycle manufacturer Bianchi S.p.A and sometimes known as Bianchi Green. In Italian, as the name indicates (Celestial), it is an attempt to reproduce the colour of clear skies. In English, this colour may also be referred to as Italian sky blue.