Note

Note, notes, or NOTE may refer to:

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Technology and science

Australian one-dollar note

The Australian one dollar note (or $1 bill) was introduced in 1966 due to decimalisation, to replace the 10 shilling note which had similar brown colouration. The note was issued from its introduction in 1966 until its replacement by the one dollar coin in 1984. Approximately 1.7 billion one dollar notes were printed.

Printing

During the note's issue, between its introduction and 1974, The note bore "Commonwealth of Australia" as the identification of country. At least 680,000,000 notes were printed in this time period. After 1974 and until the dollar coin was introduced in 1984, the note bore "Australia" as its identification of country. Around 1,020,000,000 such notes were printed after 1974.

Design

The Australian one dollar note was designed by Gordon Andrews, the design being accepted in April 1964. The note features Queen Elizabeth II wearing Garter robes on the obverse with the Australian coat of arms. This portrait was based on a photo taken by Douglas Glass. The reverse of the note features Aboriginal contemporary art, created by David Malangi. The artwork depicts the "mortuary feast" of one of the artist's creation ancestors, Gunmirringu, the great ancestral hunter. The Manharrngu people attribute this story as the origin of their mortuary rites.

Samsung Galaxy Note 4

The Samsung Galaxy Note 4 is an Android phablet smartphone developed and produced by Samsung Electronics. The Galaxy Note 4 was unveiled during a Samsung press conference at IFA Berlin on 3 September 2014 and was released globally in October 2014. It is the successor to the Samsung Galaxy Note 3, with the subsequent model unveiled on 13 August 2015.

Specifications

Hardware

The Samsung Galaxy Note 4 features a 2560×1440 Quad HD (QHD) WQ HD Super AMOLED 5.7-inch display with 2.5D damage-resistant Gorilla Glass 4, and provides a pixel density of 515 ppi (pixels-per-inch). The Note 4 comes in two variants, one powered by a 2.7 GHz quad-core Snapdragon 805 chipset with Adreno 420 GPU, the other powered by Samsung’s ARMv8-A Exynos 7 Octa SoC with two clusters of four cores; four Cortex-A57 cores at 1.9 GHz, and four Cortex-A53 cores at 1.3 GHz, which is the same processor cluster sold for the Samsung Galaxy Note 3 in markets that mostly use or only have 3G (Such as HSUPA and HSPA), and/or '2G', such as unaltered GSM and CDMA networks, similar to how the Galaxy Note 3 is sold. The phone has metal edges with a plastic, faux leather back. The China model is TD-LTE and TD-SCDMA Plus Network.

Sigma Seven

Sigma Seven Co., Ltd. (株式会社シグマ・セブン, Kabushiki-gaisha Shiguma Sebun) is a Japanese talent management firm representing a fair number of voice actors and entertainers. Founded on March 3, 1988, Sigma Seven is headquartered on the third floor of the Haga Building in Minato, Tokyo, Japan.

Notable voice actors

Female

Male

References

External links

Sigma factor

A sigma factor (σ factor) is a protein needed only for initiation of RNA synthesis. It is a bacterial transcription initiation factor that enables specific binding of RNA polymerase to gene promoters. The specific sigma factor used to initiate transcription of a given gene will vary, depending on the gene and on the environmental signals needed to initiate transcription of that gene.

Every molecule of RNA polymerase holoenzyme contains exactly one sigma factor subunit, which in the model bacterium Escherichia coli is one of those listed below. The number of sigma factors varies between bacterial species.E. coli has seven sigma factors. Sigma factors are distinguished by their characteristic molecular weights. For example, σ⁷⁰ refers to the sigma factor with a molecular weight of 70 kDa.

RNA polymerase holoenzyme complex consisting of core RNA polymerase and a sigma factor executes transcription of a DNA template strand. Once initiation of RNA transcription is complete, the sigma factor can leave the complex.

Sigma-1 receptor

The sigma-1 receptor (σ₁R), one of two sigma receptor subtypes, is a chaperone protein at the endoplasmic reticulum (ER) that modulates calcium signaling through the IP3 receptor. In humans, the σ₁ receptor is encoded by the SIGMAR1 gene.

The σ₁ receptor is a transmembrane protein expressed in many different tissue types. It is particularly concentrated in certain regions of the central nervous system. It has been implicated in myriad phenomena, including cardiovascular function, schizophrenia, clinical depression, the effects of cocaine abuse, and cancer. Much is known about the binding affinity of hundreds of synthetic compounds to the σ₁ receptor.

An endogenous ligand for the σ₁ receptor has yet to be conclusively identified, but tryptaminergic trace amines, as well as neuroactive steroids such as dehydroepiandrosterone (DHEA) and pregnenolone all activate the receptor.

Characteristics

The σ₁ receptor is defined by its unique pharmacological profile. In 1976 Martin reported that the effects of N-allylnormetazocine (SKF-10,047) could not be due to activity at the μ and κ receptors (named from the first letter of their selective ligands morphine and ketazocine, respectively) and a new type of opioid receptor was proposed; σ (from the first letter of SKF-10,047). However, ligands acting at this new “opioid” receptor were not blocked by the classical opioid antagonists naloxone and naltrexone. Consequently, the opioid classification was eventually dropped and the receptor was later termed the σ₁ receptor. It was found to have affinity for the (+)-stereoisomers of several benzomorphans (e.g., (+)-pentazocine and (+)-cyclazocine), various structurally and pharmacologically distinct psychoactive chemicals such as haloperidol and cocaine, and neuroactive steroids like progesterone.

Sick

Sick may refer to:

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People with the surname