BTK
BTK may refer to:
Biology
Business
Music
Other
Birth Through Knowledge
Birth Through Knowledge (aka BTK) was a Canadian hip-hop/rock band best known for their 1998 single "Peppyrock," the video for which was nominated for the 1998 MuchMusic Best Video Award. The band consisted of Lo-Ki (vocals), Stone Groove (vocals), DJ Spinz (turntables), Adam Carlo (bass),Sam Cino (drums,percussion) and Matt deMatteo (drums).
After signing onto the Tommyboy/Ignition label, BTK released one album "Birth Thru Knowledge" in 1998.
BTK first came to attention when their song "Corncob Pipe" was included on the sampler disc that Korn released alongside Follow the Leader. They were the first indie band to ever open the main-stage at Edgefest '97. In 1998, the band toured with the Beastie Boys and with Our Lady Peace. They appeared in the 1998 Summersault tour.
The band won the 1997 MuchMusic Best Independent Video Award for "Superchile." They were also nominated for a Juno Award in 1999 in the Best Alternative Album category, losing to Rufus Wainwright.
Footnotes
Bruton's tyrosine kinase
Bruton's tyrosine kinase (abbreviated Btk or BTK) also known as tyrosine-protein kinase BTK is an enzyme that in humans is encoded by the BTK gene. BTK is a kinase that plays a crucial role in B-cell development.
Function
BTK plays a crucial role in B cell maturation as well as mast cell activation through the high-affinity IgE receptor.
Btk contains a PH domain that binds phosphatidylinositol (3,4,5)-trisphosphate (PIP3). PIP3 binding induces Btk to phosphorylate phospholipase C, which in turn hydrolyzes PIP2, a phosphatidylinositol, into two second messengers, inositol triphosphate (IP3) and diacylglycerol (DAG), which then go on to modulate the activity of downstream proteins during B-cell signalling.
Clinical significance
Mutations in the BTK gene are implicated in the primary immunodeficiency disease X-linked agammaglobulinemia (Bruton's agammaglobulinemia). Patients with XLA have normal pre-B cell populations in their bone marrow but these cells fail to mature and enter the circulation. The Btk gene is located on the X chromosome. At least 400 mutations of the BTK gene have been identified.
Shredding
Shredding, shred, or shredder may refer to:
Equipment
Music
Computing
Film
Other
Shredder (software)
Shredder is a commercial chess program and Chess engine developed in Germany by Stefan Meyer-Kahlen in 1993. Shredder won the World Microcomputer Chess Championship in 1996 and 2000, the World Computer Chess Championship in 1999 and 2003, the World Computer Speed Chess Championship in 2002, 2003, 2004, 2005, and 2007, and the World Chess Software Championship in 2010.
On the January 24, 2007 CEGT rating list, Deep Shredder 10.0 placed fifth, with a rating of 2855 — 5 points below LoopMp, 22 points below Deep Fritz 10, and 160 points below #1 ranked Rybka 2.1, which had a rating of 3015.
Version 10.0 was released in June 2006. Version 11.0 was released in October 2007. Version 12 was released in January 2010. The "Deep" version takes advantage of multiple CPUs or multiple core CPUs.
Awards
Shredder has won a number of computer chess tournaments since its inception:
Platforms
Shredder is one of the few commercial chess programs which is available not only for Windows and Mac OS, but also for Linux. Shredder is also available on the iPhone, the iPad and Android.
Shredder (film)
Shredder is a 2003 horror film directed by Greg Huson. It stars Scott Weinger and Lindsey McKeon and centers on a group of friends being stalked and murdered by an unknown figure at an abandoned ski resort. Filmed in Northern Idaho at Silver Mountain Ski Resort, the old lodge before the expansion will look familiar to skiers from the early 80's.
Plot
Chad (Elliot Olson) is snowboarding down a mountain, when suddenly a skier dressed in black attacks him. Chad attempts to get away, but is decapitated by a piece of wire strung up between two trees. Meanwhile, college student Kimberly (Lindsey McKeon) is going on a trip to an abandoned ski resort, which her father will be buying soon, with her boyfriend Cole (Scott Weinger), cousin Pike (Juleah Weikel), and friends Skyler (Billy O'Sullivan), Robyn (Holly Towne) and Kirk (Peter Riggs). While stopping off at a gas station, the group bump into the European Christophe (Brad Hawkins), who they quickly invite along with them.
Cole and Skyler go back into town to retrieve beer, but are warned away from the resort by a bartender, Bud (Ron Varela). Skyler also briefly meets Bud's daughter Shelly (Candace Moon) to whom he takes a liking. Arriving back at the resort, the group partake in drinking games until the town Sheriff (Seth Reston) shows up. Kimberly and Robyn manage to bribe him to let them stay there for the night, however as the Sheriff leaves the cabin he is stabbed to death. Kimberly then tells the others that a few years previous, a group of snowboarders murdered a young girl at the resort, and that's why it had closed down.
Podcasts:
