Sheep

The sheep (Ovis aries) is a quadrupedal, ruminant mammal typically kept as livestock. Like all ruminants, sheep are members of the order Artiodactyla, the even-toed ungulates. Although the name "sheep" applies to many species in the genus Ovis, in everyday usage it almost always refers to Ovis aries. Numbering a little over one billion, domestic sheep are also the most numerous species of sheep. An adult female sheep is referred to as a ewe (/juː/), an intact male as a ram or occasionally a tup, a castrated male as a wether, and a younger sheep as a lamb.

Sheep are most likely descended from the wild mouflon of Europe and Asia. One of the earliest animals to be domesticated for agricultural purposes, sheep are raised for fleece, meat (lamb, hogget or mutton) and milk. A sheep's wool is the most widely used animal fiber, and is usually harvested by shearing. Ovine meat is called lamb when from younger animals and mutton when from older ones. Sheep continue to be important for wool and meat today, and are also occasionally raised for pelts, as dairy animals, or as model organisms for science.

Sheep (video game)

Sheep is a strategy puzzle video game released for PlayStation, Microsoft Windows and Game Boy Advance. In 2001 it was released for OS X by Feral Interactive.

Gameplay

Sheep bears some resemblance to the video game Lemmings. The player can choose between 4 herders, the people Adam Halfpint and Bo Peep, and the dogs Motley and Shep.

The player must then guide sheep of 4 types (Factoral, Longwool, NeoGenetic, and Pastoral), actually aliens from the planet Ovis Aries, through a series of obstacles to the finish line in the level.

There are a series of different worlds, starting with Polygon Farm and on to others, such as Village Fete and Lost in Space. If you collect all the golden sheep trophies in a world, you get to play a bonus game, devised from some other, like Snake (in this version, you are riding a sheep, and have to collect the trapped sheep in bubbles).

The obstacles between you and victory vary from world to world, including tractors, knights, archers and demonic chefs. Eventually, you must thwart the schemes of the mad scientist Mr. Pear and his hench-cows.

Sheep (disambiguation)

Sheep are quadrupedal, ruminant mammals that are typically kept as livestock.

Sheep may also refer to:

See also

TCP

TCP may refer to:

Science and technology

Computing

Medicine

Chemistry

Organizations

CCL5

Chemokine (C-C motif) ligand 5 (also CCL5) is a protein which in humans is encoded by the CCL5 gene. It is also known as RANTES (regulated on activation, normal T cell expressed and secreted).

Function

CCL5 is an 8kDa protein classified as a chemotactic cytokine or chemokine. CCL5 is chemotactic for T cells, eosinophils, and basophils, and plays an active role in recruiting leukocytes into inflammatory sites. With the help of particular cytokines (i.e., IL-2 and IFN-γ) that are released by T cells, CCL5 also induces the proliferation and activation of certain natural-killer (NK) cells to form CHAK (CC-Chemokine-activated killer) cells. It is also an HIV-suppressive factor released from CD8+ T cells. This chemokine has been localized to chromosome 17 in humans.

RANTES was first identified in a search for genes expressed "late" (3–5 days) after T cell activation. It was subsequently determined to be a CC chemokine and expressed in more than 100 human diseases. RANTES expression is regulated in T lymphocytes by Kruppel like factor 13 (KLF13). RANTES, along with the related chemokines MIP-1alpha and MIP-1beta, has been identified as a natural HIV-suppressive factor secreted by activated CD8+ T cells and other immune cells. Recently, the RANTES protein has been engineered for in vivo production by Lactobacillus bacteria, and this solution is being developed into a possible HIV entry-inhibiting topical microbicide.

T-complex 1

T-complex protein 1 subunit alpha is a protein that in humans is encoded by the TCP1 gene.

Function

This gene encodes a molecular chaperone that is a member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Alternate transcriptional splice variants of this gene, encoding different isoforms, have been characterized.

Interactions

T-complex 1 has been shown to interact with PPP4C and HDAC3. CCT also directly interacts with lectin type oxidized LDL receptor-1 (LOX-1) while its ligand oxidized low density lipoprotein (OxLDL) disassociates CCT from LOX-1.

References

Further reading