Shadows (1922 film)

Shadows is a dramatic 1922 silent film starring Lon Chaney, Marguerite De La Motte, Harrison Ford and John St. Polis. Shadows is a tale of deception, sacrifice and humility by a gentle Chinese immigrant in a small New England town directed by Tom Forman.

Plot

A boastful and proud yet abusive fisherman by the name of Daniel Gibbs (Walter Long) leaves his wife Sympathy (De La Motte) to go on a fishing expedition with other villagers from their village of Urkey and is lost at sea. Two men survive, one villager and a mysterious Chinese stranger named Yen Sin (Chaney). Being Chinese and refusing to take part in Christian service for those lost, he is made an outcast and forced to live on a small boat in the harbor. He makes his living doing laundry from his boat, and is soon greeted by the new minister, John Malden (Ford), who tries unsuccessfully to convert him. Love blossoms between Reverend Malden and Sympathy, and they are soon married, to the chagrin of the wealthiest member of the village, Nate Snow (St. Polis). Sympathy soon befriends Yen Sin after she observes several kids taunting him in the street.

Shadows (novel)

Shadows is a novel written by British author Tim Bowler and was first published in 1999. The Young Telegraph described the novel as having 'lots of pace, action and a couple of shocking twists!' It tells the story of Jamie, a 16-year-old living in Ashingford who used to enjoy playing squash. It is revealed in the book that he stopped liking the sport after his family moved to Ashingford.

Jamie is under pressure from his father to succeed. In the competitive world of squash, his dad is determined that Jamie should succeed where he failed. The emotional and physical bullying that Jamie has to endure makes him recoil into himself until he feels backed into a corner and doesn't know where to turn.

But Jamie does't share his father's single-minded ambition and is desperate to escape from the verbal and physical abuse that follows when he fails. Then Jamie finds the girl hiding in his shed, and in helping her to escape from her past and the danger that is pursuing her, he is able to put his own problems in perspective and realize that he must come out of the shadows and face up to his father.

Civilization: Beyond Earth

Sid Meier's Civilization: Beyond Earth is a turn-based strategy, 4X video game in the Civilization series developed by Firaxis Games, published by 2K Games and released for Microsoft Windows on October 24, 2014, the Mac App Store on November 27, 2014 and for Linux on December 18, 2014. A spiritual successor to Alpha Centauri, Beyond Earth shares much of that game's development team, as well as some concepts which were introduced in the 1999 title. The game's setting is unique to the Civilization series in that it takes place in the future, with mankind traveling through space and founding colonies on extraterrestrial planets after Earth becomes uninhabitable due to an undescribed disaster known as "the Great Mistake".

An expansion pack, titled Rising Tide, was released on October 9, 2015.

Gameplay

Beyond Earth is a turn-based strategy game played on a hexagonal-based grid, iterating the ideas and building upon the engine of its predecessor, Civilization V. Co-lead designer David McDonough described the relationship between the two games by saying "The bones of the experience are very much recognisably Civ. The idea of the cities, city-base progression, leaders, the passage of time, tile-based, turn-based, building improvements, technologies. A lot of them are very familiar themes to the Civ player."

Spinal and bulbar muscular atrophy

Spinal and bulbar muscular atrophy (SBMA), also known as spinobulbar muscular atrophy, bulbo-spinal atrophy, X-linked bulbospinal neuropathy (XBSN), X-linked spinal muscular atrophy type 1 (SMAX1), Kennedy's disease (KD), and many other names — is a debilitating neurodegenerative disorder resulting in muscle cramps and progressive weakness due to degeneration of motor neurons in the brain stem and spinal cord.

The condition is associated with mutation of the androgen receptor (AR) gene and is inherited in an X-linked recessive manner. As with many genetic disorders, no cure is known, although research continues.

Because of its endocrine manifestations related to the impairment of the AR gene, SBMA can be viewed as a variation of the disorders of the androgen insensitivity syndrome (AIS). It is also related to other neurodegenerative diseases caused by similar mutations, such as Huntington's disease and the spinocerebellar ataxias.

Genetics

The androgen receptor gene that is mutated in SBMA is located on the X chromosome, and the effects of the mutation may be androgen-dependent, thus only males are fully affected. Females are rarely affected; female carriers tend to have a relatively mild expression of the disease if they show symptoms at all.