Sertindole

Sertindole (brand names: Serdolect and Serlect) is an antipsychotic medication. Sertindole was developed by the Danish pharmaceutical company Lundbeck and marketed under license by Abbott Labs. Like other atypical antipsychotics, it has activity at dopamine and serotonin receptors in the brain. It is used in the treatment of schizophrenia. It is classified chemically as a phenylindole derivative.

Sertindole is not approved for use in the United States.

Medical Uses

Sertindole appears effective as an antipsychotic in schizophrenia. It may have a favorable side effect profile, and efficacy similar to risperidone.

Adverse effects

Very common (>10% incidence) adverse effects include:

Headache

Ejaculation failure

Insomnia

Dizziness

Common (1–10% incidence) adverse effects include:

Urine that tests positive for red and/or white blood cells

Sedation (causes less sedation than most antipsychotic drugs according to a recent meta-analysis of the efficacy and tolerability of 15 antipsychotic drugs. Causes only slightly [and non-significantly] more sedation than amisulpride and paliperidone)

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Sertindole

Medical Uses

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