TPM

TPM may refer to:

Organisations

  • Tea Party movement, an American political movement named after the Boston Tea Party
  • The Pentecostal Mission, a Pentecostal religious denomination in Tamil Nadu, India
  • Publishing

  • The Philosophers' Magazine, an independent quarterly magazine about philosophy
  • The Photographer's Mail, a photography industry magazine in New Zealand
  • Talking Points Memo, a political blog run by Joshua Marshall
  • Technology

  • Technical protection measures, the use of technological tools in order to restrict the use or access to a work
  • Tivoli Provisioning Manager, a software product by IBM
  • Total productive maintenance, an equipment maintenance program
  • Trade promotion management, software that supports the management of trade promotion
  • Trusted Platform Module, a specification for a secure cryptoprocessor included with some computers
  • TPG Telecom (Australian Securities Exchange symbol)
  • Other uses

  • Technology Park Malaysia, a research and development centre
  • Tethered particle motion, a biophysical single-molecule experiment method
  • Tropomyosin 3

    Tropomyosin alpha-3 chain is a protein that in humans is encoded by the TPM3 gene.

    This gene encodes a member of the tropomyosin family of actin-binding proteins involved in the contractile system of striated and smooth muscles and the cytoskeleton of non-muscle cells. Tropomyosins are dimers of coiled-coil proteins that polymerize end-to-end along the major groove in most actin filaments. They provide stability to the filaments and regulate access of other actin-binding proteins. In muscle cells, they regulate muscle contraction by controlling the binding of myosin heads to the actin filament. Mutations in this gene result in autosomal dominant nemaline myopathy, and oncogenes formed by chromosomal translocations involving this locus are associated with cancer. Multiple transcript variants encoding different isoforms have been found for this gene.

    References

    External links

  • GeneReviews/NCBI/NIH/UW entry on Nemaline Myopathy
  • Further reading


    TPM2

    β-Tropomyosin, also known as tropomyosin beta chain is a protein that in humans is encoded by the TPM2 gene. β-tropomyosin is striated muscle-specific coiled coil dimer that functions to stabilize actin filaments and regulate muscle contraction.

    Structure

    β-tropomyosin is roughly 32 kDa in molecular weight (284 amino acids), but multiple splice variants exist. Tropomysin is a flexible protein homodimer or heterodimer composed of two alpha-helical chains, which adopt a bent coiled coil conformation to wrap around the seven actin molecules in a functional unit of muscle. It is polymerized end to end along the two grooves of actin filaments and provides stability to the filaments. Tropomyosin dimers are composed of varying combinations of tropomyosin isoforms; human striated muscles express protein from the TPM1 (α-tropoomyosin), TPM2 (β-tropomyosin) and TPM3 (γ-tropomyosin) genes, with α-tropomyosin being the predominant isoform in striated muscle. Fast skeletal muscle and cardiac muscle contain more αα-homodimers, and slow skeletal muscle contains more ββ-homodimers. In human cardiac muscle the ratio of α-tropomyosin to β-tropomyosin is roughly 5:1. It has been shown that different combinations of tropomyosin isoforms bind troponin T with differing affinities, demonstrating that isoform combinations are used to impart a specific functional impact.

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    PNP chief calls for enhanced community engagement to bridge crime perception gap

    Sun Star 30 Mar 2025
    He said that while law enforcement agencies have made significant strides in crime prevention and resolution, the way incidents are reported and shared can sometimes create a heightened sense of insecurity ... (TPM/SunStar Philippines) ....
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