Hereditary multiple exostoses

Hereditary multiple exostoses (HME or MHE), also known as Diaphyseal aclasis, is a rare medical condition in which multiple bony spurs or lumps (also known as exostoses, or osteochondromas) develop on the bones of a child. HME is synonymous with Multiple hereditary exostoses and Multiple osteochondromatosis, which is the preferred term used by the World Health Organization.

Pathophysiology

It is characterized by the growth of cartilage-capped benign bone tumours around areas of active bone growth, particularly the metaphysis of the long bones. Typically five or six exostoses are found in upper and lower limbs. Most common locations are:

HME can lead to the shortening and bowing of bones; affected individuals often have a short stature. Depending on their location the exostoses can cause the following problems: pain or numbness from nerve compression, vascular compromise, inequality of limb length, irritation of tendon and muscle, Madelung's deformity as well as a limited range of motion at the joints upon which they encroach. A person with HME has an increased risk of developing a rare form of bone cancer called chondrosarcoma as an adult. Problems may be had in later life and these could include weak bones and nerve damage. The reported rate of transformation ranges from as low as 0.57% to as high as 8.3% of people with HME.

Satisfied

Satisfied may refer to:

Satisfied (Richard Marx song)

"Satisfied" is a chart-topping hit song recorded by American rock singer Richard Marx for his second album, Repeat Offender. It was Richard's second of three consecutive #1 on the Billboard Hot 100 singles chart.

Charts

"Satisfied" was the lead single from Richard Marx's highly anticipated second album, Repeat Offender. Heavy radio, video and retail attention led to the single's #39 debut on the Billboard Hot 100 singles chart, during the week of May 6, 1989. The single steadily climbed to the top, reaching the #1 spot the week of June 24, 1989. "Satisfied" was the first of five Top 15 singles from Marx's second studio album, which kept the artist on the singles chart consecutively for well over a year during 1989 and 1990.

References

External links

Choose Love

Choose Love is the fourteenth studio album by Ringo Starr, released in 2005.

Background and recording

Recorded throughout 2004 into 2005, using the same team that created Vertical Man (1998) and Ringo Rama (2003), Starr produced the set with longtime musical partner Mark Hudson and performed it with their studio team. The title track, Choose Love has a Beatles-like Day Tripper guitar riff and mentions the Beatles songs "The Long and Winding Road", Tomorrow Never Knows, and What Goes On. As ever, a Starr album would be lacking if it did not include some celebrity guests and Choose Love does not deviate from the formula; it features Billy Preston and Chrissie Hynde as its most notable guests.

Release

Choose Love was released on 7 June 2005 in the US, and on 25 July in the UK. There was an edition of the album that was a dual disc (CD on side, DVD on the other), with the DVD component featuring bonus features on the making of the album.

Reception

Choose Love failed to chart in the UK and even in the US, where both Vertical Man and Ringo Rama had seen a measure of commercial success. The album received strong reviews upon its release and preceded another promotional tour with Starr and his studio band, called "The Roundheads".