| Synaptic vesicle glycoprotein 2A | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||||||
| Symbols | SV2A; SV2 | ||||||||||||
| External IDs | OMIM: 185860 MGI: 1927139 HomoloGene: 32237 ChEMBL: 1998 GeneCards: SV2A Gene | ||||||||||||
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| RNA expression pattern | |||||||||||||
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| More reference expression data | |||||||||||||
| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 9900 | 64051 | |||||||||||
| Ensembl | ENSG00000159164 | ENSMUSG00000038486 | |||||||||||
| UniProt | Q7L0J3 | Q9JIS5 | |||||||||||
| RefSeq (mRNA) | NM_014849.3 | NM_022030.3 | |||||||||||
| RefSeq (protein) | NP_055664.3 | NP_071313.1 | |||||||||||
| Location (UCSC) | Chr 1: 149.87 – 149.89 Mb |
Chr 3: 95.99 – 96 Mb |
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| PubMed search | [1] | [2] | |||||||||||
Synaptic vesicle glycoprotein 2A is a ubiquitous synaptic vesicle protein that in humans is encoded by the SV2A gene.[1][2][3] The protein is targeted by the anti-epileptic drug (AED) levetiracetam.[4]
References [link]
- ^ Bajjalieh SM, Peterson K, Linial M, Scheller RH (Apr 1993). "Brain contains two forms of synaptic vesicle protein 2". Proc Natl Acad Sci U S A 90 (6): 2150–4. DOI:10.1073/pnas.90.6.2150. PMC 46043. PMID 7681585. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=46043.
- ^ Crowder KM, Gunther JM, Jones TA, Hale BD, Zhang HZ, Peterson MR, Scheller RH, Chavkin C, Bajjalieh SM (Jan 2000). "Abnormal neurotransmission in mice lacking synaptic vesicle protein 2A (SV2A)". Proc Natl Acad Sci U S A 96 (26): 15268–73. DOI:10.1073/pnas.96.26.15268. PMC 24809. PMID 10611374. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=24809.
- ^ "Entrez Gene: SV2A synaptic vesicle glycoprotein 2A". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9900.
- ^ Ulloa CM, Towfigh A, Safdieh J (2009). "Review of levetiracetam, with a focus on the extended release formulation, as adjuvant therapy in controlling partial-onset seizures". Neuropsychiatr Dis Treat 5: 467–76. PMC 2747386. PMID 19777068. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2747386.
Further reading [link]
- Bajjalieh SM, Peterson K, Shinghal R, Scheller RH (1992). "SV2, a brain synaptic vesicle protein homologous to bacterial transporters.". Science 257 (5074): 1271–3. DOI:10.1126/science.1519064. PMID 1519064.
- Nagase T, Ishikawa K, Suyama M, et al. (1999). "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.". DNA Res. 5 (5): 277–86. DOI:10.1093/dnares/5.5.277. PMID 9872452.
- Son YJ, Scranton TW, Sunderland WJ, et al. (2000). "The synaptic vesicle protein SV2 is complexed with an alpha5-containing laminin on the nerve terminal surface.". J. Biol. Chem. 275 (1): 451–60. DOI:10.1074/jbc.275.1.451. PMID 10617638.
- Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination.". Genome Res. 10 (11): 1788–95. DOI:10.1101/gr.143000. PMC 310948. PMID 11076863. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=310948.
- Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.". Genome Res. 11 (3): 422–35. DOI:10.1101/gr.GR1547R. PMC 311072. PMID 11230166. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=311072.
- Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing.". EMBO Rep. 1 (3): 287–92. DOI:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1083732.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. DOI:10.1073/pnas.242603899. PMC 139241. PMID 12477932. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
- Lynch BA, Lambeng N, Nocka K, et al. (2004). "The synaptic vesicle protein SV2A is the binding site for the antiepileptic drug levetiracetam.". Proc. Natl. Acad. Sci. U.S.A. 101 (26): 9861–6. DOI:10.1073/pnas.0308208101. PMC 470764. PMID 15210974. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=470764.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. DOI:10.1101/gr.2596504. PMC 528928. PMID 15489334. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.
- Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline.". Genome Res. 14 (10B): 2136–44. DOI:10.1101/gr.2576704. PMC 528930. PMID 15489336. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528930.
- DeGiorgis JA, Jaffe H, Moreira JE, et al. (2005). "Phosphoproteomic analysis of synaptosomes from human cerebral cortex.". J. Proteome Res. 4 (2): 306–15. DOI:10.1021/pr0498436. PMID 15822905.
- Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries.". DNA Res. 12 (2): 117–26. DOI:10.1093/dnares/12.2.117. PMID 16303743.
- Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006.". Nucleic Acids Res. 34 (Database issue): D415–8. DOI:10.1093/nar/gkj139. PMC 1347501. PMID 16381901. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1347501.
- Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1.". Nature 441 (7091): 315–21. DOI:10.1038/nature04727. PMID 16710414.
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