SMT3 suppressor of mif two 3 homolog 2 (S. cerevisiae)

PDB rendering based on 1u4a.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols SUMO2; HSMT3; SMT3B; SMT3H2; SUMO3; Smt3A
External IDs OMIM: 603042 MGI: 2158813 HomoloGene: 87858 GeneCards: SUMO2 Gene
Orthologs
Species Human Mouse
Entrez 6613 100043429
Ensembl ENSG00000188612 ENSMUSG00000020738
UniProt P61956 P61957
RefSeq (mRNA) NM_001005849.1 NM_133354
RefSeq (protein) NP_001005849.1 NP_579932
Location (UCSC) Chr 17:
73.16 – 73.18 Mb		 Chr 11:
115.38 – 115.4 Mb
PubMed search [1] [2]
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Small ubiquitin-related modifier 2 is a protein that in humans is encoded by the SUMO2 gene.[1]

This gene encodes a protein that is a member of the SUMO (small ubiquitin-like modifier) protein family. It functions in a manner similar to ubiquitin in that it is bound to target proteins as part of a post-translational modification system. However, unlike ubiquitin which targets proteins for degradation, this protein is involved in a variety of cellular processes, such as nuclear transport, transcriptional regulation, apoptosis, and protein stability. It is not active until the last two amino acids of the carboxy-terminus have been cleaved off. Numerous pseudogenes have been reported for this gene. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.[2]

Interactions [link]

SUMO2 has been shown to interact with TRIM63[3] and c21orf59 [4].

References [link]

  1. ^ Mannen H, Tseng HM, Cho CL, Li SS (June 1996). "Cloning and expression of human homolog HSMT3 to yeast SMT3 suppressor of MIF2 mutations in a centromere protein gene". Biochem Biophys Res Commun 222 (1): 178–80. DOI:10.1006/bbrc.1996.0717. PMID 8630065. 
  2. ^ "Entrez Gene: SUMO2 SMT3 suppressor of mif two 3 homolog 2 (S. cerevisiae)". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6613. 
  3. ^ Dai, K S; Liew C C (June 2001). "A novel human striated muscle RING zinc finger protein, SMRZ, interacts with SMT3b via its RING domain". J. Biol. Chem. (United States) 276 (26): 23992–9. DOI:10.1074/jbc.M011208200. ISSN 0021-9258. PMID 11283016. 
  4. ^ Golebiowski, F.; Matic, I.; Tatham, M. H.; Cole, C.; Yin, Y.; Nakamura, A.; Cox, J.; Barton, G. J. et al. (2009). "System-Wide Changes to SUMO Modifications in Response to Heat Shock". Science Signaling 2 (72): ra24. DOI:10.1126/scisignal.2000282. PMID 19471022.  edit

Further reading [link]



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Heart Has A Mind Of Its Own

by: Sammie

you don't get to tell your heart how to feel
it does what it wants when it wants to
all that you can do is pray that it lands in the hands of somebody true!
and you don't get to tell your heart where to stay
no it will not obey cause it knows the truth
let's not confuse it! you try to prove it wrong
but the heart has a mind of its own
chorus:
you can't run from the place that you belong
cause if you run, you'll be feeling so alone
before you know, you'll be picking up the phone
cause the heart has a mind of its own!
can't fight that burning in your chest
you can't fight, feeling such a mess
your hear decides, but it's you that second guest
cause the heart has a mind of its own!
you don't get to fall at the perfect time
for someone love is ending, for someone else is just beginning
someone is gotta cry, someone needs to know why
but the heart tells no lies!
and you don't get to tell your heart when it heels
when it breaks like rock through shatter glass
all you can ask is that the pain moves fast
one day this too, shall last!
by know i hope you know, it has a mind of its own!
chorus:
you can't run from the place that you belong
cause if you run, you'll be feeling so alone
before you know, you'll be picking up the phone
cause the heart has a mind of its own!
can't fight that burning in your chest
you can't fight, feeling such a mess
your hear decides, but it's you that second guest
cause the heart has a mind of its own!
it's so real, can't you see it?
is the heart that really means it
and the heart won't let you lie,
it won't let love be defeated!
sometimes is inconvenient,
but the real truth is you need it
cause the mind will leave you lonely
chorus:
you can't run from the place that you belong
cause if you run, you'll be feeling so alone
before you know, you'll be picking up the phone
cause the heart has a mind of its own!
can't fight that burning in your chest
you can't fight, feeling such a mess
your hear decides, but it's you that second guest




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