STAT4
STAT4 is a transcription factor belonging to the Signal Transducer and Activator of Transcription protein family. It is required for the development of Th1 cells from naive CD4+ T cells and IFN-γ production in response to IL-12.
Structure
Human as well murine STAT4 genes lie next to STAT1 gene locus suggesting that the genes arose by gene duplication.STAT proteins have several functional domains, including an N-terminal interaction domain, a central DNA-binding domain, an SH2 domain, and the C-terminal transactivation domain.
Expression
Distribution of STAT4 is restricted to myeloid cells, thymus and testis. In resting human T cells it is expressed at very low levels, but its production is amplified by PHA stimulation.
Activation
Two chains of IL-12 receptor form heterodimer after IL-12 binding and activate the receptor associated JAK kinases, termed JAK2 and TYK2. Stat4 is phosphorylated by these tyrosine kinases, homodimerizes via its SH2 domain and translocates into nucleus to activate gene transcription.
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by Sweet Tee
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by Xd Out
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by Sidd Coutto
Leave On
by: ZididadaRelease date: 30. September 2002
Album: Happy Fool
LEAN ON
(verse)
How can I divide the time youÃve left me itÃs like infinity, this night it seems so long how can I devise what is ment to be if you wont set us free IÃm here to lean on when everythingÃs going wrong, girl, just hang on
(chorus)
When everything around you breaks the foundations you have made and IÃm the only one you can lean on just know if sometimes you rely on wrong I can right it make you strong and IÃm the only one you can lean on
(verse)
We must try and find a way to save this love just wishingÃs not enough the future itÃs calling us in that sweet sweet mind a promise I fulfilled and on that we can build IÃam here to lean on when everythings going wrong..........