| Sprouty-related, EVH1 domain containing 2 | |||||||||||||
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 PDB rendering based on 2jp2. |
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| Identifiers | |||||||||||||
| Symbols | SPRED2; Spred-2 | ||||||||||||
| External IDs | OMIM: 609292 MGI: 2150019 HomoloGene: 24918 GeneCards: SPRED2 Gene | ||||||||||||
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| RNA expression pattern | |||||||||||||
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| More reference expression data | |||||||||||||
| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 200734 | 114716 | |||||||||||
| Ensembl | ENSG00000198369 | ENSMUSG00000045671 | |||||||||||
| UniProt | Q7Z698 | Q924S7 | |||||||||||
| RefSeq (mRNA) | NM_001128210.1 | NM_033523.4 | |||||||||||
| RefSeq (protein) | NP_001121682.1 | NP_277058.1 | |||||||||||
| Location (UCSC) | Chr 2: 65.54 – 65.66 Mb |
Chr 11: 19.82 – 19.92 Mb |
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| PubMed search | [1] | [2] | |||||||||||
Sprouty-related, EVH1 domain-containing protein 2 is a protein that in humans is encoded by the SPRED2 gene.[1]
Contents |
Function [link]
SPRED2 is a member of the Sprouty (see SPRY1)/SPRED family of proteins that regulate growth factor-induced activation of the MAP kinase cascade (see MAPK1.[1]
References [link]
Further reading [link]
- Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction.". Anal. Biochem. 236 (1): 107–13. DOI:10.1006/abio.1996.0138. PMID 8619474.
- Yu W, Andersson B, Worley KC, et al. (1997). "Large-scale concatenation cDNA sequencing.". Genome Res. 7 (4): 353–8. DOI:10.1101/gr.7.4.353. PMC 139146. PMID 9110174. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139146.
- Wakioka T, Sasaki A, Kato R, et al. (2001). "Spred is a Sprouty-related suppressor of Ras signalling.". Nature 412 (6847): 647–51. DOI:10.1038/35088082. PMID 11493923.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. DOI:10.1073/pnas.242603899. PMC 139241. PMID 12477932. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
- Kato R, Nonami A, Taketomi T, et al. (2003). "Molecular cloning of mammalian Spred-3 which suppresses tyrosine kinase-mediated Erk activation.". Biochem. Biophys. Res. Commun. 302 (4): 767–72. DOI:10.1016/S0006-291X(03)00259-6. PMID 12646235.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. DOI:10.1038/ng1285. PMID 14702039.
- Nobuhisa I, Kato R, Inoue H, et al. (2004). "Spred-2 suppresses aorta-gonad-mesonephros hematopoiesis by inhibiting MAP kinase activation.". J. Exp. Med. 199 (5): 737–42. DOI:10.1084/jem.20030830. PMC 2213301. PMID 14981116. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2213301.
- Miyoshi K, Wakioka T, Nishinakamura H, et al. (2004). "The Sprouty-related protein, Spred, inhibits cell motility, metastasis, and Rho-mediated actin reorganization.". Oncogene 23 (33): 5567–76. DOI:10.1038/sj.onc.1207759. PMID 15184877.
- Zimmermann J, Jarchau T, Walter U, et al. (2005). "1H, 13C and 15N resonance assignment of the human Spred2 EVH1 domain.". J. Biomol. NMR 29 (3): 435–6. DOI:10.1023/B:JNMR.0000032526.17586.8c. PMID 15213456.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. DOI:10.1101/gr.2596504. PMC 528928. PMID 15489334. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.
- Engelhardt CM, Bundschu K, Messerschmitt M, et al. (2005). "Expression and subcellular localization of Spred proteins in mouse and human tissues.". Histochem. Cell Biol. 122 (6): 527–38. DOI:10.1007/s00418-004-0725-6. PMID 15580519.
- King JA, Straffon AF, D'Abaco GM, et al. (2005). "Distinct requirements for the Sprouty domain for functional activity of Spred proteins.". Biochem. J. 388 (Pt 2): 445–54. DOI:10.1042/BJ20041284. PMC 1138951. PMID 15683364. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1138951.
- Bundschu K, Knobeloch KP, Ullrich M, et al. (2005). "Gene disruption of Spred-2 causes dwarfism.". J. Biol. Chem. 280 (31): 28572–80. DOI:10.1074/jbc.M503640200. PMID 15946934.
- Yoshida T, Hisamoto T, Akiba J, et al. (2006). "Spreds, inhibitors of the Ras/ERK signal transduction, are dysregulated in human hepatocellular carcinoma and linked to the malignant phenotype of tumors.". Oncogene 25 (45): 6056–66. DOI:10.1038/sj.onc.1209635. PMID 16652141.
- Lock P, I ST, Straffon AF, et al. (2007). "Spred-2 steady-state levels are regulated by phosphorylation and Cbl-mediated ubiquitination.". Biochem. Biophys. Res. Commun. 351 (4): 1018–23. DOI:10.1016/j.bbrc.2006.10.150. PMID 17094949.
External links [link]
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https://wn.com/SPRED2
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