SPN may refer to:
Organizations:
In other areas:
Leukosialin also known as sialophorin or CD43 (cluster of differentiation 43) is a transmembrane cell surface protein that in humans is encoded by the SPN (sialophorin) gene.
Sialophorin (leukosialin) is a major sialoglycoprotein on the surface of human T lymphocytes, monocytes, granulocytes, and some B lymphocytes, which appears to be important for immune function and may be part of a physiologic ligand-receptor complex involved in T-cell activation.
Defects in the CD43 molecule are associated with the development of Wiskott-Aldrich syndrome. It also appears in about 25% of intestinal MALTomas. Using immunohistochemistry, CD43 can be demonstrated in the paracortical T-cells of healthy lymph nodes and tonsils; it is also positive in a range of lymphoid and myeloid tumours. Although it is present in over 90% of T-cell lymphomas, it is generally less effective at demonstrating this condition than is CD3 antigen. However, it may be useful as part of a panel to demonstrate B-cell lymphoblastic lymphoma, since the malignant cells in this condition are often CD43 positive, and may be difficult to stain with other antibodies. Because it stains granulocytes and their precursors, it is also an effective marker for myeloid tumours.
Snurportin1 is a protein that in humans is encoded by the SNUPN gene.
The nuclear import of the spliceosomal snRNPs U1, U2, U4 and U5, is dependent on the presence of a complex nuclear localization signal. The latter is composed of the 5'-2,2,7-terminal trimethylguanosine (m3G) cap structure of the U snRNA and the Sm core domain. The protein encoded by this gene interacts specifically with m3G-cap and functions as an snRNP-specific nuclear import receptor. Alternatively spliced transcript variants encoding the same protein have been identified for this gene.
I got nothing, you got something, I feel out of place
Looking through your window into the delicate place
Reflections stating obvious mating holds
I'll own up to you if you own up to me
I'll picture for you if you picture for me
Have you got the answer? Have I yet won the part?
Is this just your way of breaking my heart?
Everyone denies it but they just want to be told
I'll hold if for you if you hold it for me
I'll picture for you if you picture for me
The delicate place, the questions it raise
The delicate place, the delicate place
I got nothing, you got something, I feel out of place
Looking through that window into the delicate place
I'll own up to you if you own up to me
I'll picture for you if you picture for me
The delicate place, the questions it raise
The delicate place, yeah, the delicate place, yeah