 |
This article is an orphan, as few or no other articles link to it. Please introduce links to this page from related articles; suggestions may be available. (February 2009) |
| Sperm autoantigenic protein 17 | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||||||
| Symbols | SPA17; CT22; SP17; SP17-1 | ||||||||||||
| External IDs | OMIM: 608621 MGI: 1333778 HomoloGene: 7951 GeneCards: SPA17 Gene | ||||||||||||
|
|||||||||||||
| RNA expression pattern | |||||||||||||
 |
|||||||||||||
| More reference expression data | |||||||||||||
| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 53340 | 20686 | |||||||||||
| Ensembl | ENSG00000064199 | ENSMUSG00000001948 | |||||||||||
| UniProt | Q15506 | Q62252 | |||||||||||
| RefSeq (mRNA) | NM_017425.3 | NM_011449.2 | |||||||||||
| RefSeq (protein) | NP_059121.1 | NP_035579.1 | |||||||||||
| Location (UCSC) | Chr 11: 124.54 – 124.57 Mb |
Chr 9: 37.41 – 37.42 Mb |
|||||||||||
| PubMed search | [1] | [2] | |||||||||||
Sperm surface protein Sp17 is a protein that in humans is encoded by the SPA17 gene.[1][2]
This gene encodes a protein present at the cell surface. Studies in rabbit suggest that in sperm the protein is involved in fertilization by binding to the zona pellucida of the oocyte. Other studies in rabbit suggest that it is also involved in additional cell-cell adhesion functions such as immune cell migration and metastasis.[2]
References [link]
- ^ Lea IA, Richardson RT, Widgren EE, O'Rand MG (Aug 1996). "Cloning and sequencing of cDNAs encoding the human sperm protein, Sp17". Biochim Biophys Acta 1307 (3): 263–6. PMID 8688458.
- ^ a b "Entrez Gene: SPA17 sperm autoantigenic protein 17". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=53340.
Further reading [link]
- McLeskey SB, Dowds C, Carballada R, et al. (1997). "Molecules involved in mammalian sperm-egg interaction". Int. Rev. Cytol. 177: 57–113. DOI:10.1016/S0074-7696(08)62231-7. PMID 9378618.
- Richardson RT, Yamasaki N, O'Rand MG (1994). "Sequence of a rabbit sperm zona pellucida binding protein and localization during the acrosome reaction". Dev. Biol. 165 (2): 688–701. DOI:10.1006/dbio.1994.1285. PMID 7525387.
- Kong M, Richardson RT, Widgren EE, O'Rand MG (1995). "Sequence and localization of the mouse sperm autoantigenic protein, Sp17". Biol. Reprod. 53 (3): 579–90. DOI:10.1095/biolreprod53.3.579. PMID 7578682.
- Fujita A, Nakamura K, Kato T, et al. (2000). "Ropporin, a sperm-specific binding protein of rhophilin, that is localized in the fibrous sheath of sperm flagella". J. Cell. Sci. 113 (1): 103–12. PMID 10591629.
- Wen Y, Richardson RT, Widgren EE, O'Rand MG (2001). "Characterization of Sp17: a ubiquitous three domain protein that binds heparin". Biochem. J. 357 (Pt 1): 25–31. DOI:10.1042/0264-6021:3570025. PMC 1221924. PMID 11415432. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1221924.
- De Jong A, Buchli R, Robbins D (2003). "Characterization of sperm protein 17 in human somatic and neoplastic tissue". Cancer Lett. 186 (2): 201–9. DOI:10.1016/S0304-3835(02)00350-6. PMID 12213290.
- Buchli R, De Jong A, Robbins DL (2002). "Genomic organization of an intron-containing sperm protein 17 gene (Sp17-1) and an intronless pseudogene (Sp17-2) in humans: a new model". Biochim. Biophys. Acta 1578 (1–3): 29–42. DOI:10.1016/S0167-4781(02)00478-5. PMID 12393185.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. DOI:10.1073/pnas.242603899. PMC 139241. PMID 12477932. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
- Frayne J, Hall L (2003). "A re-evaluation of sperm protein 17 (Sp17) indicates a regulatory role in an A-kinase anchoring protein complex, rather than a unique role in sperm-zona pellucida binding". Reproduction 124 (6): 767–74. DOI:10.1530/rep.0.1240767. PMID 12530914.
- Takeoka Y, Kenny TP, Yago H, et al. (2004). "Developmental considerations of sperm protein 17 gene expression in rheumatoid arthritis synoviocytes". Dev. Immunol. 9 (2): 97–102. DOI:10.1080/1044667021000095186. PMC 2276097. PMID 12739786. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2276097.
- Chiriva-Internati M, Wang Z, Pochopien S, et al. (2004). "Identification of a sperm protein 17 CTL epitope restricted by HLA-A1". Int. J. Cancer 107 (5): 863–5. DOI:10.1002/ijc.11486. PMID 14566839.
- Straughn JM, Shaw DR, Guerrero A, et al. (2004). "Expression of sperm protein 17 (Sp17) in ovarian cancer". Int. J. Cancer 108 (6): 805–11. DOI:10.1002/ijc.11617. PMID 14712480.
- Lea IA, Widgren EE, O'Rand MG (2004). "Association of sperm protein 17 with A-kinase anchoring protein 3 in flagella". Reprod. Biol. Endocrinol. 2: 57. DOI:10.1186/1477-7827-2-57. PMC 484205. PMID 15257753. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=484205.
- Wang Z, Zhang Y, Ramsahoye B, et al. (2004). "Sp17 gene expression in myeloma cells is regulated by promoter methylation". Br. J. Cancer 91 (8): 1597–603. DOI:10.1038/sj.bjc.6602160. PMC 2409933. PMID 15381930. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2409933.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. DOI:10.1101/gr.2596504. PMC 528928. PMID 15489334. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.
- Gupta G, Sharma R, Chattopadhyay TK, et al. (2007). "Clinical significance of sperm protein 17 expression and immunogenicity in esophageal cancer". Int. J. Cancer 120 (8): 1739–47. DOI:10.1002/ijc.22463. PMID 17230514.
 |
This article on a gene on chromosome 11 is a stub. You can help Wikipedia by expanding it. |
https://wn.com/SPA17
Podcasts:
PLAYLIST TIME:
-
by Subb
-
by Subb
-
by Subb
-
by S.O.A.P.
-
by Saybia
-
by Saybia
-
by S.O.A.P.
-
by S.O.A.P.
-
by S.O.A.P.
-
by S.O.A.P.
-
by S.O.A.P.
-
by S.O.A.P.
-
by S.O.A.P.
-
by S.O.A.P.
-
by S.O.A.P.
-
by S.O.A.P.
-
by S.O.A.P.
-
by S.O.A.P.
-
by S.O.A.P.
-
by S.O.A.P.
-
by S.O.A.P.
-
by Saybia
-
by Saybia
-
by S.O.A.P.
-
by S.O.A.P.
-
by S.O.A.P.
-
by S.O.A.P.
-
by S.O.A.P.
-
by S.O.A.P.
-
by Saybia
-
by Saybia
-
by S.O.A.P.
-
by Zuba
-
by Zuba
-
by Zuba
-
by Zuba
-
by Zuba
-
by Zuba
-
by Zuba
-
by Zuba
-
by Zuba
-
by Zuba
-
by Zuba
-
by Zuba
-
by Zuba
-
by Zuba
-
by Zuba
-
by Zuba
-
by Zuba
'Diskathing
by: SubbYou may not care but don't be naive
Well take The best The positive aspect
Have some friends and a punkska band
I guess that's The key to your sobriety
Even if you're a pervert use your head
Before you date this girl, you better sure you've bled
It's o.k. you'll do some mistakes
Like Ace Ventura with Snowflakes
Ohhhhhhhhhhhhhh!
Life is like diskathing
And someday you'll have a lovely wife
You'll do like O.J. and kill her with a knife
You'll obey to your bastard dog
Live across The street from a big fat slob
You will be a fucking statistic
Another man without a diploma
But after all you'll be happy
Cause you know man, this is The key
[Chorus]
[Bridge]
[Solo]
Ba-ba-ba, ba-Barbara ann!!! [x3]
[Chorus]