SOX12 is a protein that in humans is encoded by the SOX12 gene. Sox12 belongs to the SoxC group of Sox family of transcription factors, together with Sox4 and Sox11. Sox12-null knockout mice appear normal, unlike Sox4 or Sox11 knockout mice. This probably comes from functional redundancy with Sox4 and Sox11. Sox12 is a weaker activator than both Sox4 and Sox11 in mouse.
Members of the SOX family of transcription factors are characterized by the presence of a DNA-binding high mobility group (HMG) domain, homologous to the HMG box of sex-determining region Y (SRY). Forming a subgroup of the HMG domain superfamily, SOX proteins have been implicated in cell fate decisions in a diverse range of developmental processes. SOX transcription factors have diverse tissue-specific expression patterns during early development and have been proposed to act as target-specific transcription factors and/or as chromatin structure regulatory elements. The protein encoded by this gene was identified as a SOX family member based on conserved domains and its expression in various tissues suggests a role in both differentiation and maintenance of several cell types.
[Chorus]
Choice of the chosen, yeah
Choice of the chosen, yeah
Choice of the chosen, yeah
Choice of the chosen, yeah
[Verse 1]
When the people of the power meet the power of the
people,
Then it changes every hour of the day,
All you need is one man with his head in the sand,
To rise up and say,
It's the regime of a beauty queen,
You gotta come clean cause you're a liar,
But if you stand up and fight for the things that are
right,
Then you'll find one day you start a fire,
And when that flame burns,
The people start to learn,
It's all you need to take you higher,
Higher than the trees and the birds and the bees,
It's the flame that we call desire, yeah
[Chorus]
Choice of the chosen, yeah
Choice of the chosen, yeah
Choice of the chosen, yeah
Choice of the chosen, yeah
[Verse 2]
It's the man at the docks working off the clock,
Who's a time bomb ready to explode,
Can we find a way to make it through the day,
Please tell me cause I don't know,
And then one day he goes boom,
His mind begins to break,
The weight upon his shoulders is too much for him to
take,
Sick of living his life by the edge of a knife,
Yeah he's gone
Said he's gone,
Never to return,
'Cause you know his flame will never ever burn again,
again
Again, again
Again, again
Again, yeah yeah
[Chorus]
Choice of the chosen, yeah
Choice of the chosen, yeah
Choice of the chosen, yeah
Choice of the chosen, yeah
[Verse 3]
I was on my way just the other day,
When a man said I've got a problem,
I have everything that money can bring,
But I can't stop the wind from blowing,
I could sympathize with the pain in his eyes,
When I told him he'd fade to nothing,
You can try to change,
When you pass the blame,
But you know it's the choice of the chosen, yeah
[Chorus]
Choice of the chosen, yeah
Choice of the chosen, yeah
Choice of the chosen, yeah
Choice of the chosen, yeah
Said it's the choice of the chosen, yeah