SOX11

Transcription factor SOX-11 is a protein that in humans is encoded by the SOX11 gene.

Function

This intronless gene encodes a member of the group C SOX (SRY-related HMG-box) transcription factor family involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins. The protein may function in the developing nervous system and play a role in tumorigenesis and adult neurogenesis. Tuj1 and Tead2 are suggested as direct target of Sox11.

Clinical aspect

Mutations in SOX11 are associated to Coffin-Siris syndrome .

See also

  • SOX genes
  • References

    Further reading

    Podcasts:

    PLAYLIST TIME:

    Choice Of The Chosen

    by: Six60

    [Chorus]
    Choice of the chosen, yeah
    Choice of the chosen, yeah
    Choice of the chosen, yeah
    Choice of the chosen, yeah
    [Verse 1]
    When the people of the power meet the power of the
    people,
    Then it changes every hour of the day,
    All you need is one man with his head in the sand,
    To rise up and say,
    It's the regime of a beauty queen,
    You gotta come clean cause you're a liar,
    But if you stand up and fight for the things that are
    right,
    Then you'll find one day you start a fire,
    And when that flame burns,
    The people start to learn,
    It's all you need to take you higher,
    Higher than the trees and the birds and the bees,
    It's the flame that we call desire, yeah
    [Chorus]
    Choice of the chosen, yeah
    Choice of the chosen, yeah
    Choice of the chosen, yeah
    Choice of the chosen, yeah
    [Verse 2]
    It's the man at the docks working off the clock,
    Who's a time bomb ready to explode,
    Can we find a way to make it through the day,
    Please tell me cause I don't know,
    And then one day he goes boom,
    His mind begins to break,
    The weight upon his shoulders is too much for him to
    take,
    Sick of living his life by the edge of a knife,
    Yeah he's gone
    Said he's gone,
    Never to return,
    'Cause you know his flame will never ever burn again,
    again
    Again, again
    Again, again
    Again, yeah yeah
    [Chorus]
    Choice of the chosen, yeah
    Choice of the chosen, yeah
    Choice of the chosen, yeah
    Choice of the chosen, yeah
    [Verse 3]
    I was on my way just the other day,
    When a man said I've got a problem,
    I have everything that money can bring,
    But I can't stop the wind from blowing,
    I could sympathize with the pain in his eyes,
    When I told him he'd fade to nothing,
    You can try to change,
    When you pass the blame,
    But you know it's the choice of the chosen, yeah
    [Chorus]
    Choice of the chosen, yeah
    Choice of the chosen, yeah
    Choice of the chosen, yeah
    Choice of the chosen, yeah
    Said it's the choice of the chosen, yeah




    ×