SOX10
Transcription factor SOX-10 is a protein that in humans is encoded by the SOX10 gene.
Function
This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional activator after forming a protein complex with other proteins. This protein acts as a nucleocytoplasmic shuttle protein and is important for neural crest and peripheral nervous system development.
In melanocytic cells there is evidence that SOX10 gene expression may be regulated by MITF.
Clinical significance
Mutations in this gene are associated with Waardenburg-Shah, Waardenburg-Hirschsprung disease, and with uveal melanoma .
Interactions
The interaction between SOX10 and PAX3 is studied best in human patients with Waardenburg syndrome, an autosomal dominant disorder which is divided into four different types based upon mutations in additional genes. SOX10 and PAX3 interactions are thought to be regulators of other genes involved in the symptoms of Waardenburg syndrome, particularly MITF which influences the development of melanocytes as well as neural crest formation. MITF expression can be transactivated by both SOX10 and PAX3 to have an additive effect. The two genes have binding sites near one another on the upstream enhancer of the c-RET gene. SOX10 is also thought to target dopachrome tautomerase through a synergistic interaction with MITF which then results in other melanocyte alteration.
Podcasts:
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by Six60
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by Six60
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by Six60
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by Six60
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by Six60
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by Six60
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by Six60
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by Six60
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by Six60
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by Six60
Choice Of The Chosen
by: Six60[Chorus]
Choice of the chosen, yeah
Choice of the chosen, yeah
Choice of the chosen, yeah
Choice of the chosen, yeah
[Verse 1]
When the people of the power meet the power of the
people,
Then it changes every hour of the day,
All you need is one man with his head in the sand,
To rise up and say,
It's the regime of a beauty queen,
You gotta come clean cause you're a liar,
But if you stand up and fight for the things that are
right,
Then you'll find one day you start a fire,
And when that flame burns,
The people start to learn,
It's all you need to take you higher,
Higher than the trees and the birds and the bees,
It's the flame that we call desire, yeah
[Chorus]
Choice of the chosen, yeah
Choice of the chosen, yeah
Choice of the chosen, yeah
Choice of the chosen, yeah
[Verse 2]
It's the man at the docks working off the clock,
Who's a time bomb ready to explode,
Can we find a way to make it through the day,
Please tell me cause I don't know,
And then one day he goes boom,
His mind begins to break,
The weight upon his shoulders is too much for him to
take,
Sick of living his life by the edge of a knife,
Yeah he's gone
Said he's gone,
Never to return,
'Cause you know his flame will never ever burn again,
again
Again, again
Again, again
Again, yeah yeah
[Chorus]
Choice of the chosen, yeah
Choice of the chosen, yeah
Choice of the chosen, yeah
Choice of the chosen, yeah
[Verse 3]
I was on my way just the other day,
When a man said I've got a problem,
I have everything that money can bring,
But I can't stop the wind from blowing,
I could sympathize with the pain in his eyes,
When I told him he'd fade to nothing,
You can try to change,
When you pass the blame,
But you know it's the choice of the chosen, yeah
[Chorus]
Choice of the chosen, yeah
Choice of the chosen, yeah
Choice of the chosen, yeah
Choice of the chosen, yeah
Said it's the choice of the chosen, yeah