Suppressor of cytokine signaling 1
Suppressor of cytokine signaling 1 is a protein that in humans is encoded by the SOCS1 gene.SOCS1 orthologs have been identified in several mammals for which complete genome data are available.
This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signalling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by a subset of cytokines, including IL2, IL3 erythropoietin (EPO), GM-CSF, and interferon-gamma (IFN-γ). The protein encoded by this gene functions downstream of cytokine receptors, and takes part in a negative feedback loop to attenuate cytokine signaling. Knockout studies in mice suggested the role of this gene as a modulator of IFN-γ action, which is required for normal postnatal growth and survival.
See also
Interactions
Suppressor of cytokine signaling 1 has been shown to interact with:
Podcasts:
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by Siouxsie
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by Siouxsie
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by Siouxsie
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by Sexys
Into A Swan
by: SiouxsieWhat in the world is happening?
What in the world could this be?
I'm on the verge of an awakening
A new kind of strength for me
I feel a force I've never felt before
I don't want to fight it anymore
Feelings so strong can't be ignored
I burst out, I'm transformed
Rising up, shaking it up, a yesterday dreary
Graceful and strong, no more for long
Today's a jubilee
Don't be surprised this change is my design
I feel a force I've never felt before
I don't want to fight it anymore
Feelings so strong can't be ignored
I burst out, I'm transformed
I feel a force I've never felt before
I can't hold it down I've just got to soar
And laugh in the face that is vulture law
I burst out, I'm transformed
I feel a force I've never felt before
I don't want to fight it anymore
Feelings so strong can't be ignored
I burst out, I'm transformed
I feel a force I've never felt before
I can't hold it down I've just got to soar
And laugh in the face that is vulture law
I burst out, I'm transformed
I burst right out into a swan
I burst out into a swan
I feel a force
I don't want to fight it
I feel a force