Staphylococcal nuclease domain-containing protein 1 also known as 100 kDa coactivator or Tudor domain-containing protein 11 (TDRD11) is a protein that in humans is encoded by the SND1 gene. SND1 is a main component of RISC complex and plays an important role in miRNA function. SND1 is Tudor Domain containing protein and Tudor Proteins are highly conserved proteins and even present in Drosophila melanogaster. SND1 is also involved in Autism.
SND1 acts as oncogene in many cancers and in hepatocellular carcinoma progression. SND1 promotes tumor angiogenesis in human hepatocellular carcinoma through a novel pathway which involves NF-kappaB and miR-221. SND1 promotes migration and invasion via angiotensin II type 1 receptor and TGFβ signaling. SND1 expression is regulated by Mir-184 in gliomas.
SND1 has been shown to interact with MYB,
SND1 also interacts with G3BP (stress granule protein) and AEG-1.
Toby:
Ladies and Gentlemen!
May I have your attention please?
Do you wake every morning in shame and despair
To discover your pillow is covered with hair...
What ought not to be there?
Well, ladies and gentlemen,
From now on you can waken at ease!
You need never again have a worry or care,
I will show you a miracle marvelous rare!
Gentlemen, you are about to see something what rose
from the dead--!
...On the top of my head!
Twas Pirelli's Miracle Elixir
That's what did the trick, sir,
True, sir, true.
Was it quick, sir? Did it in a tick, sir!
Just like an elixir ought to do!
How about a bottle, mister?
Only costs a penny, guaranteed!
Does Pirelli's stimulate the growth, sir?
You can have my oath, sir, 'tis unique.
Rub a minute - stimulatin', in'it?
Soon you'll have to thin it once a week!
Sweeney:
Pardon me, ma'am, what's that awful stench?
Mrs. Lovett:
Are we standing near an open trench?
(Sweeney: Are we standing near an open trench?)
(Mrs. Lovett: Pardon me, sir, what's that awful stench?
Toby:
Buy Pirelli's Miracle elixir
Anything wot's slick, sir,
Soon sprouts curls.
Try Pirelli's; when they see how thick, sir,
You can have your pick, sir, of the girls!
Toby: Wanna buy a bottle, missus?
Sweeney: What is this?
Mrs. Lovett: What is this?
Sweeney: Smells like piss...
Mrs. Lovett: Smells like "EW!"
Sweeney: Looks like piss...
(Mrs. Lovett: Wouldn't touch it if I were you, dear!)
Sweeney: This is piss, piss with ink.
Toby:
Let Pirelli's activate your roots, sir--
Sweeney:
Keep it off your boots, sir! Eats right through!
Toby:
YES, get Pirelli's, use a bottle of it; ladies seem to
love it--
Mrs. Lovett: