SMYD3
SET and MYND domain-containing protein 3 is a protein that in humans is encoded by the SMYD3 gene.
Function
SMYD3 is a histone methyltransferase that plays a role in transcriptional regulation as a member of an RNA polymerase complex.
Model organisms
Model organisms have been used in the study of SMYD3 function. A conditional knockout mouse line, called Smyd3tm2a(KOMP)Wtsi was generated as part of the International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists — at the Wellcome Trust Sanger Institute.
Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion. Twenty three tests were carried out on homozygous mutant adult mice, however no significant abnormalities were observed.
Interactions
SMYD3 has been shown to interact with Heat shock protein 90kDa alpha (cytosolic), member A1 and POLR2A.
SMYD3 trimethylates a lysine residue on MAP3K2, which causes crosstalk into the MAP kinase signaling pathway in Ras-driven cancers.
Podcasts:
-
by Carman
Some - O - Dat
by: CarmanWell I got this friend named T.J. Clyde
Who sees this strength of God inside
So he says to me, "Hey, I want Some-O-Dat"
I say Clyde it's easy as one, two, three
You just say this simple prayer with me
He said, "Not me Bubba, but I still want Some-O-Dat"
OOh Some-O-Dat
Well I was sharing with this sales man Lyle
So he says with a million dollar smile
"Why that's interesting you know. Hey I'd like Some-O-Dat."
I said "Lyle you're gonna have to humble your pride and ask the Lord to come inside."
He said, "No-ho-ho-ho, but I still want Some-O-Dat."
Ooh Some-O-Dat
Well you can't find it
In astrology
That horoscope that you read is just a waste
You can't find it looking at the stars
Jupiter, the moon and Mars.
Cause you'll soon find that all you got was space.
Well my best friends Ray has got this niece
That sees within my eyes this peace
And yesterday she said
"I want Some-O-Dat"
Well I said "Hey Sugar, Now it's a breeze
Just talk with Jesus on your knees
She said, "I'm not the type but I still want Some-O-Dat"
Ooh they all want Some-O-Dat
Brother you can't find it
In a bottle
Or even when you pop a pill or two
You can't find it smoking dope or weed
Cause one fine day you're gonna see
That the dope that's being smoked my friend is you
Well if you're depressed
Then get used to it
Cause without Jesus
You have blew it
He's the only one who can give you Some-O-Dat
Why not try the Lord for goodness sake
You'll be happy as a dog with a T-bone steak