The initials SMG may refer to:
SMG$ is a library of screen management routines for OpenVMS. These routines allow programs to create text-based, terminal interfaces in a terminal-independent manner. This is similar in concept to the ncurses library made popular under UNIX.
Telomerase-binding protein EST1A is an enzyme that in humans is encoded by the SMG6 gene. The C-terminus of the EST1A protein contains a PIN domain. This structure for this domain has been determined by X-ray crystallography.