Mothers against decapentaplegic homolog 4
SMAD 4, also called SMAD family member n°4 or Mothers against decapentaplegic homolog 4, is a protein involved in cell signaling in mammals. It belongs to the proteins of the SMAD family.
SMAD 4 participates in chain reactions inside cells where it interacts with other members of the SMAD family such as SMAD2 or SMAD3. SMAD 4 forms with SMAD 3 a complex which can bind to DNA and modify the expression of several genes related to cellular activities such as proliferation or differentiation. The complex SMAD 3-SMAD 4 is therefore a transcription factor. Intracellular reactions involving SMAD 4 are triggered by the binding, on the surface of the cells, of growth factors from the TGFβ family. The sequence of intracellular reactions involving SMADS is called the SMAD pathway or the transforming growth factor beta (TGF-β) pathway since the sequence starts with the recognition of TGF-β by cells.
SMAD 4 belongs to the co-SMAD group, the second class of the SMAD family. SMAD 4 is the only known co-SMAD in mammals. It also belongs to the Darwin family of proteins that modulate members of the TGFβ protein superfamily, a family of proteins that all play a role in the regulation of cellular responses. Mammalian SMAD 4 is a homolog of the Drosophila protein "Mothers against decapentaplegic" or MAD.
Podcasts:
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by Carman
Some - O - Dat
by: CarmanWell I got this friend named T.J. Clyde
Who sees this strength of God inside
So he says to me, "Hey, I want Some-O-Dat"
I say Clyde it's easy as one, two, three
You just say this simple prayer with me
He said, "Not me Bubba, but I still want Some-O-Dat"
OOh Some-O-Dat
Well I was sharing with this sales man Lyle
So he says with a million dollar smile
"Why that's interesting you know. Hey I'd like Some-O-Dat."
I said "Lyle you're gonna have to humble your pride and ask the Lord to come inside."
He said, "No-ho-ho-ho, but I still want Some-O-Dat."
Ooh Some-O-Dat
Well you can't find it
In astrology
That horoscope that you read is just a waste
You can't find it looking at the stars
Jupiter, the moon and Mars.
Cause you'll soon find that all you got was space.
Well my best friends Ray has got this niece
That sees within my eyes this peace
And yesterday she said
"I want Some-O-Dat"
Well I said "Hey Sugar, Now it's a breeze
Just talk with Jesus on your knees
She said, "I'm not the type but I still want Some-O-Dat"
Ooh they all want Some-O-Dat
Brother you can't find it
In a bottle
Or even when you pop a pill or two
You can't find it smoking dope or weed
Cause one fine day you're gonna see
That the dope that's being smoked my friend is you
Well if you're depressed
Then get used to it
Cause without Jesus
You have blew it
He's the only one who can give you Some-O-Dat
Why not try the Lord for goodness sake
You'll be happy as a dog with a T-bone steak