Mothers against decapentaplegic homolog 2
Mothers against decapentaplegic homolog 2 also known as SMAD family member 2 or SMAD2 is a protein that in humans is encoded by the SMAD2 gene. MAD homolog 2 belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways.
Function
SMAD2 mediates the signal of the transforming growth factor (TGF)-beta, and thus regulates multiple cellular processes, such as cell proliferation, apoptosis, and differentiation. This protein is recruited to the TGF-beta receptors through its interaction with the SMAD anchor for receptor activation (SARA) protein. In response to TGF-beta signal, this protein is phosphorylated by the TGF-beta receptors. The phosphorylation induces the dissociation of this protein with SARA and the association with the family member SMAD4. The association with SMAD4 is important for the translocation of this protein into the cell nucleus, where it binds to target promoters and forms a transcription repressor complex with other cofactors. This protein can also be phosphorylated by activin type 1 receptor kinase, and mediates the signal from the activin. Alternatively spliced transcript variants encoding the same protein have been observed.
Podcasts:
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by Carman
Some - O - Dat
by: CarmanWell I got this friend named T.J. Clyde
Who sees this strength of God inside
So he says to me, "Hey, I want Some-O-Dat"
I say Clyde it's easy as one, two, three
You just say this simple prayer with me
He said, "Not me Bubba, but I still want Some-O-Dat"
OOh Some-O-Dat
Well I was sharing with this sales man Lyle
So he says with a million dollar smile
"Why that's interesting you know. Hey I'd like Some-O-Dat."
I said "Lyle you're gonna have to humble your pride and ask the Lord to come inside."
He said, "No-ho-ho-ho, but I still want Some-O-Dat."
Ooh Some-O-Dat
Well you can't find it
In astrology
That horoscope that you read is just a waste
You can't find it looking at the stars
Jupiter, the moon and Mars.
Cause you'll soon find that all you got was space.
Well my best friends Ray has got this niece
That sees within my eyes this peace
And yesterday she said
"I want Some-O-Dat"
Well I said "Hey Sugar, Now it's a breeze
Just talk with Jesus on your knees
She said, "I'm not the type but I still want Some-O-Dat"
Ooh they all want Some-O-Dat
Brother you can't find it
In a bottle
Or even when you pop a pill or two
You can't find it smoking dope or weed
Cause one fine day you're gonna see
That the dope that's being smoked my friend is you
Well if you're depressed
Then get used to it
Cause without Jesus
You have blew it
He's the only one who can give you Some-O-Dat
Why not try the Lord for goodness sake
You'll be happy as a dog with a T-bone steak