Skp1

Skp1 (S-phase kinase-associated protein 1) is a small protein of approximately 160 amino acids. As a core component of the SCF-type E3 ubiquitin ligases that mediate protein degradation by the 26S proteosome, Skp1 plays key roles in cell-cycle progression, transcriptional regulation, signal transduction, and many other cellular processes in eukaryotes.

References

Hellmann, H. and Estelle, M. (2002) Plant development: regulation by protein degradation. Science, 297, 793–797.

SKP1A

S-phase kinase-associated protein 1 is an enzyme that in humans is encoded by the SKP1 gene.

This gene encodes a protein that is a member of the SCF ubiquitin ligase protein complex. It binds to F-box proteins (proteins containing an F-box motif), such as cyclin F, S-phase kinase-associated protein 2, and other regulatory proteins involved in ubiquitin dependent proteolysis. The encoded protein also collaborates with a network of proteins to control beta-catenin levels and affects the activity level of beta-catenin dependent TCF transcription factors. Studies have also characterized the protein as an RNA polymerase II elongation factor. Alternative splicing of this gene results in two transcript variants. A related pseudogene has been identified on chromosome 7.

Interactions

SKP1A has been shown to interact with:

References

Further reading