SKF-83,959

SKF-83,959 is a synthetic benzazepine derivative used in scientific research which acts as an agonist at the D₁-D₂ dopamine receptor. It behaves as a full agonist at the D₁protomer and a high-affinity partial agonist at the D₂ protomer. It was further shown to act as an allosteric modulator of the sigma-1 receptor. SKF-83,959 is a racemate that consists of the R-(+)- and S-(−)-enantiomers MCL 202 and MCL 201, respectively. SKF-83,959 inhibits sodium channels as well as delayed rectifier potassium channels.

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